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Effect of yellowing time on bioactive compounds in yellow tea and their antiproliferative capacity in HepG2 cells

文献类型： 外文期刊

作者： An, Ran 1 ; Sun, Lingli 2 ; Xiang, Limin 2 ; Zhang, Wenji 2 ; Li, Qiuhua 2 ; Lai, Xingfei 2 ; Wen, Shuai 1 ; Huo, Mengen; 1 ;

作者机构： 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

2.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utiliza, Guangzhou 510640, Guangdong, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China

关键词： anticancer; antioxidation; bioactive component; yellow tea; yellowing time

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2019 年 7 卷 5 期

页码：

收录情况： SCI

摘要： Several studies have shown potent antineoplastic effects of tea, which can induce apoptosis and inhibit proliferation of cancer cells. Yellow tea is one of the six major types of tea, and yellowing time, a key factor in its processing, is known to improve its quality and bioactivity. However, the effects of yellowing on the composition of the bioactive substances of tea are poorly understood. We analyzed the biochemical composition and the antioxidant and anticancer activities of the extracts of yellow tea (EYTs) subjected to different yellowing durations. Prolonged yellowing increased the content of water extracts, amino acids, soluble sugars, theaflavins, and nonesterified catechins (p 0.05, p < 0.01) and decreased that of polyphenols, flavonols, thearubigins, caffeine, GA, and esterified catechins (p 0.05, p < 0.01). In addition, yellowing also slightly increased the antioxidant capacity of the EYTs, but did not significantly affect their ability to inhibit the proliferation of the hepatocarcinoma HepG2 cells. Mechanistically, the EYTs significantly downregulated the phosphorylation of PI3K and AKT and upregulated the Bax/Bcl-2 ratio in the HepG2 cells. Taken together, the yellowing time influences the bioactive components of yellow tea, and the resulting yellow tea may have more potent antioxidant and anticancer effects.

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