Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites
文献类型： 外文期刊
作者： Li, Qian 1 ; Liu, Fan 1 ; Liu, Jun 1 ; Liao, Sentai 1 ; Zou, Yuxiao 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangdong Key Lab Agr Prod Proc, Guangzhou 510610, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Minist Agr & Rural Affairs, Key Lab Funct Food, Guangzhou 510610, Guangdong, Peoples R China
关键词： mulberry leaf; obesity; gut microbiota; metabolomics
期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）
ISSN： 2072-6643
年卷期： 2019 年 11 卷 5 期
页码：
收录情况： SCI
摘要： The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. The results demonstrated that the MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups.
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