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Network pharmacology-based research on the active component and mechanism of the antihepatoma effect of Rubia cordifolia L.

文献类型： 外文期刊

作者： Xiong, Yiyi 1 ; Yang, Yanfang 1 ; Xiong, Weichen 1 ; Yao, Yunfeng 1 ; Wu, Hezhen 1 ; Zhang, Meide 5 ;

作者机构： 1.Hubei Univ Chinese Med, Fac Pharm, Wuhan 430065, Hubei, Peoples R China

2.Key Lab Tradit Chinese Med Resources & Chem Hubei, Wuhan, Hubei, Peoples R China

3.Collaborat Innovat Ctr Tradit Chinese Med New Pro, Wuhan, Hubei, Peoples R China

4.Hubei Univ Chinese Med, Minist Educ, Key Lab Tradit Chinese Med Resource & Compound Pr, Wuhan, Hubei, Peoples R China

5.Hubei Acad Agr Sci, Inst Chinese Herbal Med, Enshi 445000, Hubei, Peoples R China

关键词： component screening; liver cancer; molecular docking; network pharmacology; Rubia cordifolia L

期刊名称：JOURNAL OF CELLULAR BIOCHEMISTRY （ 影响因子：4.429； 五年影响因子：4.266 ）

ISSN： 0730-2312

年卷期： 2019 年 120 卷 8 期

页码：

收录情况： SCI

摘要： Rubia cordifolia L. is widely used in Asia and its antihepatoma effect has been proved by in vitro and in vivo experiments. However, there are few studies on its specific mechanism. In the present study, the network pharmacology method was used to construct the component/target/pathway molecular regulatory network for the antihepatoma effect of Rubia cordifolia L. to explore the effective components of Rubia cordifolia L. and its potential mechanism. The chemical components of Rubia cordifolia L. were identified through literature and databases, and the components were evaluated and screened by drug likeness and pharmacokinetic characteristics (ADMET). The targets of active components were predicted according to the reverse pharmacophore matching model. The hepatic carcinoma-related genes were found in databases, and antihepatoma-related gene targets were selected through comparison. The functions of target genes and related pathways were analyzed and screened using the Database for Annotation, Visualization and Integrated Discovery, and the component/target/pathways network of antihepatoma effect of Rubia cordifolia L. was constructed using Cytoscape software. Finally, 16 active compounds were screened from Rubia cordifolia L., and 39 gene targets, including AKT1, mitogen-activated protein kinase 1, and epidermal growth factor receptor, were involved. Rubia cordifolia L. also affected the hepatitis B, phosphoinositide-3-kinase-protein kinase B, and mitogen-activated protein kinase signaling pathways. Many direct-acting tumor-related signaling pathways and indirect-acting hepatitis pathways inhibit the generation of liver cancer. The present study provided a scientific basis for further elucidating the mechanism of Rubia cordifolia L. against liver cancer.

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