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Pure yeast beta-glucan and two types of yeast cell wall extracts enhance cell migration in porcine intestine model

文献类型： 外文期刊

作者： Penney, Jenna 1 ; Lu, Yang 1 ; Pan, Bo 1 ; Feng, Yulong 1 ; Walk, Carrie 3 ; Li, Julang 1 ;

作者机构： 1.Univ Guelph, Dept Anim Biosci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada

2.Shanghai Acad Agr Sci, Shanghai, Peoples R China

3.AB Vista, Woodstock Court Blenheim Rd, Marlborough SN8 4AN, Wilts, England

4.Chinese Acad Agr Sci, Inst Anim Sci, Beijing, Peoples R China

5.Foshan Univ, Dept Life Sci & Engn, Foshan, Peoples R China

关键词： Porcine intestine cells; Cell migration; Tissue repair; Beta-Glucan; Yeast cell wall

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2019 年 59 卷

页码：

收录情况： SCI

摘要： Beta-Glucans are commonly used health supplements for humans and animals. They represent a promising avenue to help combat many widespread health concerns including intestinal upset and inflammation. These beneficial effects may be different from species to species and between different cell types and therefore it is important to examine the mechanisms in any species or cell type for which this supplement may be used in. In this study we have shown that pure Beta-Glucans and the less processed yeast cell wall extracts significantly enhance cell migration in a porcine intestinal cell model, potentially through activation of the ELK1 pathway. The expression of migration-related genes was also seen to be significantly increased in response to Beta-Glucan treatment. Our data suggests that Beta-Glucans activate the CD22 receptor in the pig intestine, which has the potential to reduce inflammation. Overall, we found a novel mechanism through which Beta-Glucans exert their effects in the pig intestinal cell model.

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