Chemically protected sodium butyrate supplementation improves anti-inflammatory and antioxidant capacities potentially through modulating gut microbiota and short-chain fatty acids levels in piglets
文献类型： 外文期刊
作者： Wan, Fan 1 ; Wen, Xiaobin 1 ; Zhao, Huaibao 1 ; Tang, Shanlong 1 ; Wang, Mengyu 1 ; Yi, Bao 1 ; Chen, Liang 1 ; Lu, Yang 2 ; Zhong, Ruqing 1 ; Zhang, Hongfu 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
2.Shanghai Acad Agr Sci, Inst Anim Husb & Vet Sci, 2901 BeiDi Rd, Shanghai 201106, Peoples R China
3.Shanghai Engn Res Ctr Breeding Pig, Shanghai 201106, Peoples R China
关键词： Chemically protected sodium butyrate; Gut microbiota; Short chain fatty acids; Intestinal barrier; Piglets
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.0； 五年影响因子：4.9 ）
ISSN： 1756-4646
年卷期： 2024 年 121 卷
页码：
收录情况： SCI
摘要： Chemically protected sodium butyrate (CSB) is a novel form of sodium butyrate. This study aimed to investigate the effect of CSB supplementation on the gut mucosal immune, gut microbiota, and SCFAs in piglets. Results showed that supplementation with 2000 mg/kg (high CSB, HCSB) improved the average daily gain by 18.5 %, while supplementation with 1000 mg/kg (low CSB, LCSB) improved it by 6.9 %. qPCR results indicated HCSB treatment dramatically upregulated the mRNA expression levels of IL-10 by 47.1 %, CAT by 17.4 %, SOD1 by 48.2 %, and Claudin-1 by 50 %. Additionally, the SCFAs-producing bacteria Parabacteroides and Eubacterium coprostanoligenes were increased by HCSB supplementation. The levels of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid were significantly enhanced in the jejunal, duodenal, cecal, and colonic chyme of piglets by HCSB supplementation. Collectively, CSB supplementation improves antiinflammatory and antioxidant capacities potentially through modulating gut microbiota and SCFAs in piglets.
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