Disrupted Microbiota of Colon Results in Worse Immunity and Metabolism in Low-Birth-Weight Jinhua Newborn Piglets
文献类型： 外文期刊
作者： Li, Jiaheng 1 ; Wei, Zeou 2 ; Lou, Fangfang 1 ; Zhang, Xiaojun 1 ; Duan, Jiujun 2 ; Luo, Chengzeng 2 ; Hu, Xujin 1 ; Tu, Pingguang 1 ; Liu, Lei 2 ; Zhong, Ruqing 2 ; Chen, Liang 2 ; Du, Xizhong 1 ; Zhang, Hongfu 2 ;
作者机构： 1.Jinhua Acad Agr Sci, Inst Anim Husb & Vet Med, Jinhua 321011, Peoples R China
2.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China
3.Univ Liege, Precis Livestock & Nutr Unit, Gembloux Agrobio Tech, TERRA Teaching & Res Ctr, Passage Deportes 2, B-5030 Gembloux, Belgium
4.Univ Coll Dublin, Sch Agr & Food Sci, Dublin D04 V1W8, Ireland
关键词： Jinhua newborn piglet; low-birth-weight; microbiome; transcriptome; glucose metabolism; immunity; short chain fatty acids
期刊名称：MICROORGANISMS （ 影响因子：4.1； 五年影响因子：4.5 ）
ISSN：
年卷期： 2024 年 12 卷 7 期
页码：
收录情况： SCI
摘要： The Jinhua pig is well known in China due to its delicious meat. However, because of large litter size, low birth weight always happens. This experiment used this breed as a model to research bacterial evidence leading to growth restriction and provide a possible solution linked to probiotics. In this experiment, the differences in organs indexes, colonic morphology, short chain fatty acid (SCFA) concentrations, microbiome, and transcriptome were detected between piglets in the standard-birth-weight group (SG) and low-birth-weight group (LG) to find potential evidence leading to low birth weight. We found that LG piglets had a lower liver index (p < 0.05), deeper colonic crypt depth (p < 0.05), fewer goblet cells (p < 0.05), and more inflammatory factor infiltration. In addition, differentially expressed genes (DEGs) were mainly enriched in B-cell immunity and glucose metabolism, and LG piglets had lower concentrations of SCFAs, especially butyrate and isobutyrate (p < 0.05). Finally, most of the significantly differentially abundant microbes were fewer in LG piglets, which affected DEG expressions and SCFA concentrations further resulting in worse energy metabolism and immunity. In conclusion, colonic disrupted microbiota may cause worse glucose metabolism, immunity, and SCFA production in LG piglets, and beneficial microbes colonized in SG piglets may benefit these harmful changes.
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