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Pectin modulates intestinal immunity in a pig model via regulating the gut microbiota-derived tryptophan metabolite-AhR-IL22 pathway

文献类型： 外文期刊

作者： Dang, Guoqi 1 ; Wen, Xiaobin 1 ; Zhong, Ruqing 1 ; Wu, Weida 1 ; Tang, Shanlong 1 ; Li, Chong 3 ; Yi, Bao 1 ; Chen, Liang 1 ; Zhang, Hongfu 1 ; Schroyen, Martine 2 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

2.Univ Liege, TERRA Teaching & Res Ctr, Gembloux Agrobio Tech, Precis Livestock & Nutr Unit, Passage Deportes 2, Gembloux, Belgium

3.Chinese Acad Agr Sci, Feed Res Inst, Natl Engn Res Ctr Biol Feed, Key Lab Feed Biotechnol Minist Agr, 12 Zhongguancun South St, Beijing 100081, Peoples R China

关键词： Dietary fiber; Gut microbiota; Immune pectin; Tryptophan metabolites

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：7.0； 五年影响因子：7.3 ）

ISSN： 1674-9782

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundPectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting intestinal development and regulating intestinal flora in the gut. However, the relevant mechanisms remain obscure. In this study, pigs were fed a corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or 5% pectin for 3 weeks, to investigate the metabolites and anti-inflammatory properties of the jejunum.ResultThe results showed that dietary pectin supplementation improved intestinal integrity (Claudin-1, Occludin) and inflammatory response [interleukin (IL)-10], and the expression of proinflammatory cytokines (IL-1 beta, IL-6, IL-8, TNF-alpha) was down-regulated in the jejunum. Moreover, pectin supplementation altered the jejunal microbiome and tryptophan-related metabolites in piglets. Pectin specifically increased the abundance of Lactococcus, Enterococcus, and the microbiota-derived metabolites (skatole (ST), 3-indoleacetic acid (IAA), 3-indolepropionic acid (IPA), 5-hydroxyindole-3-acetic acid (HIAA), and tryptamine (Tpm)), which activated the aryl hydrocarbon receptor (AhR) pathway. AhR activation modulates IL-22 and its downstream pathways. Correlation analysis revealed the potential relationship between metabolites and intestinal morphology, intestinal gene expression, and cytokine levels.ConclusionIn conclusion, these results indicated that pectin inhibits the inflammatory response by enhancing the AhR-IL22-signal transducer and activator of transcription 3 signaling pathway, which is activated through tryptophan metabolites.

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