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Genome sequence analysis reveals potential for virulence genes and multi-drug resistance in an Enterococcus faecalis 2A (XJ05) strain that causes lamb encephalitis

文献类型： 外文期刊

作者： Chai, Yingjin 1 ; Gu, Xiaoxiao 1 ; Wu, Qin 1 ; Guo, Bingjiao 1 ; Qi, Yayin 1 ; Wang, Xiaolan 1 ; Zhou, Xia 1 ; Li, Jie 1 ; H 1 ;

作者机构： 1.Shihezi Univ, Coll Anim Sci & Technol, Shihezi 832000, Xinjiang, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China

关键词： Lamb encephalitis; E; faecalis; Whole genome sequencing

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2019 年 15 卷

页码：

收录情况： SCI

摘要： BackgroundEnterococcus is an important component of normal flora in human and animals, but in recent years, the pathogenicity of Enterococcus has been confirmed in clinical medicine. More and more animal infections have been reported in veterinary clinics. For the last decades, outbreaks of encephalitis in lambs have become much more common in Northern Xinjiang, China. Consequent studies have confirmed that these affected lambs had been commonly infected with E. faecalis. More than 60 E. faecalis were isolated from the brain of infected lambs, A highly virulent strain entitled E. faecalis 2A (XJ05) were selected, sequenced and analyzed.ResultUsing whole genome sequence and de novo assembly, 18 contigs with NGS and annotation were obtained. It is confirmed that the genome has a size of 2.9 Mb containing 2783 protein-coding genes, as well as 54 tRNA genes and 4 rRNA genes. Some key features of this strain were identified, which included 7 predicted antibiotic resistance genes and 18 candidate virulence factor genes.ConclusionThe E. faecalis 2A (XJ05) genome is conspicuous smaller than E.faecalis V583, but not significantly different from other non-pathogenic E. faecalis. It carried 7 resistance genes including 4 kind of antibiotics which were consistent with the results of extensive drug resistance phenotypic, including aminoglycoside, macrolide, phenicol, and tetracycline. 2A (XJ05) also carried 18 new virulence factor genes related to virulence, hemolysin genes (cylA, cylB, cylM, cylL) may play an important role in lamb encephalitis by E. faecalis 2A (XJ05).

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