Increased Inhibition Effect of Antrodin C from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), on A549 through Crosstalk between Apoptosis and Autophagy
文献类型： 外文期刊
作者： Wang, Wenhan 1 ; Yang, Hairui 1 ; Deng, Jing 3 ; Zhu, Lina 1 ; Yang, Yan 1 ; Liu, Zhendong 4 ; Zhang, Jingsong 1 ; Tang, 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Key Lab Agr Genet & Breeding, Inst Edible Fungi,Minist Agr, Natl Engn Res Ctr Edible Fungi,Key Lab Appl Myco, Shanghai, Peoples R China
2.WuXi App Tec Co Ltd, Shanghai 200131, Peoples R China
3.Sichuan Tourism Univ, Key Lab Culinary Sci, Chengdu 610100, Sichuan, Peoples R China
4.Tibet Agr & Anim Husb Univ, Food Sci Coll, Linzhi 860000, Peoples R China
关键词： apoptosis; autophagy; cell clone; cell cycle; cell migration; proliferation; reactive oxygen species; medicinal mushrooms; Taiwanofungus camphoratus
期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）
ISSN： 1521-9437
年卷期： 2019 年 21 卷 6 期
页码：
收录情况： SCI
摘要： Antrodin C was obtained from Taiwanofungus camphoratus mycelia. The inhibition effect of antrodin C on A549 lung adenocarcinoma cells was evaluated by plate clone formation, wound healing, cell cycle, activated caspase-3, Bax, P53, Bc1-2, and RAPR activities as well as reactive oxygen species release. Plate clone fonnation assay revealed that antrodin C could significantly inhibit the viability of A549 cells in vitro. Wound healing assay revealed that cell migration was inhibited by exposure to antrodin C at concentrations of 50 and 80 mu g/mL. Flow cytometry revealed that antrodin C increased the percentages of cells in the G0/G1 phase at concentrations of 50 and 80 mu g/mL and the apoptosis was related to upregulation of caspase-3, Bax, P53 expression, downregulation of Bc1-2, RAPR expression, and the release of reactive oxygen species in the A549 cells. CQ or RAPA could significantly promote or inhibit the inhibition effect on A549 proliferation induced by antrodin C, which suggests that the autophagy played a cytoprotective role on inhibition proliferation of A549 induced by antrodin C. These results indicated that the combination of pro-apoptosis agents and anti-autophagy agents may be a useful strategy in enhancing the anticancer efficacy in non-small cell lung cancer.
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