Increased Inhibition Effect of Antrodin C from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), on A549 through Crosstalk between Apoptosis and Autophagy
文献类型： 外文期刊
作者： Wang, Wenhan 1 ; Yang, Hairui 1 ; Deng, Jing 3 ; Zhu, Lina 1 ; Yang, Yan 1 ; Liu, Zhendong 4 ; Zhang, Jingsong 1 ; Tang, 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Shanghai Key Lab Agr Genet & Breeding, Inst Edible Fungi,Minist Agr, Natl Engn Res Ctr Edible Fungi,Key Lab Appl Myco, Shanghai, Peoples R China
2.WuXi App Tec Co Ltd, Shanghai 200131, Peoples R China
3.Sichuan Tourism Univ, Key Lab Culinary Sci, Chengdu 610100, Sichuan, Peoples R China
4.Tibet Agr & Anim Husb Univ, Food Sci Coll, Linzhi 860000, Peoples R China
关键词： apoptosis; autophagy; cell clone; cell cycle; cell migration; proliferation; reactive oxygen species; medicinal mushrooms; Taiwanofungus camphoratus
期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）
ISSN： 1521-9437
年卷期： 2019 年 21 卷 6 期
页码：
收录情况： SCI
摘要： Antrodin C was obtained from Taiwanofungus camphoratus mycelia. The inhibition effect of antrodin C on A549 lung adenocarcinoma cells was evaluated by plate clone formation, wound healing, cell cycle, activated caspase-3, Bax, P53, Bc1-2, and RAPR activities as well as reactive oxygen species release. Plate clone fonnation assay revealed that antrodin C could significantly inhibit the viability of A549 cells in vitro. Wound healing assay revealed that cell migration was inhibited by exposure to antrodin C at concentrations of 50 and 80 mu g/mL. Flow cytometry revealed that antrodin C increased the percentages of cells in the G0/G1 phase at concentrations of 50 and 80 mu g/mL and the apoptosis was related to upregulation of caspase-3, Bax, P53 expression, downregulation of Bc1-2, RAPR expression, and the release of reactive oxygen species in the A549 cells. CQ or RAPA could significantly promote or inhibit the inhibition effect on A549 proliferation induced by antrodin C, which suggests that the autophagy played a cytoprotective role on inhibition proliferation of A549 induced by antrodin C. These results indicated that the combination of pro-apoptosis agents and anti-autophagy agents may be a useful strategy in enhancing the anticancer efficacy in non-small cell lung cancer.
- 相关文献
作者其他论文 更多>>
-
Comprehensive evaluation of Ganoderma lucidum fermented grains: Nutritional, functional, and safety aspects
作者：Yan, Mengqiu;Jiang, Xingyi;Liu, Yanfang;Zhang, Jingsong;Feng, Jie;Yan, Mengqiu;Jiang, Xingyi;Liu, Yanfang;Zhang, Jingsong;Feng, Jie;Jiang, Xingyi
关键词：Ganoderma lucidum; Grains; Solid-state fermentation; Nutritional value; Functional efficacy; Safety
-
Nanoliposome based strategy for enhancing bioavailability and antitumor activity of polyphenol from Sanghuangporus vaninii
作者：Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Liu, Junbo;Wang, Weike
关键词：Sanghuangporus vaninii; Nanoliposome; Liver tumor; Polyphenol; Bioavailability
-
Innovative submerged directed fermentation: Producing high molecular weight polysaccharides from Ganoderma lucidum
作者：Guo, Jia;Tang, Chenmin;Liu, Yanfang;Shi, Jia;Tang, Chuanhong;Feng, Jie;Zhang, Jingsong;Guo, Jia;Vunduk, Jovana
关键词：Ganoderma lucidum; Submerged fermentation; High molecular weight polysaccharide
-
Targeted isolation and AI-based analysis of edible fungal polysaccharides: Emphasizing tumor immunological mechanisms and future prospects as mycomedicines
作者：Li, Tingting;Bi, Yong;Li, Tingting;Rui, Chuang;Ren, Lu;Wang, Qin;Dai, Mingcheng;Yang, Yan
关键词：Keywords; Edible fungal polysaccharide; Structural characterization; Gut microbiota; Tumor microenvironment; Mycomedicines; Deep learning; Glycan structure prediction"
-
Novel Umami Peptides from Lentinula edodes: Evaluation of the Umami Enhancing Effect Using Biosensors and Molecular Simulation
作者：Zhao, Shilong;Cui, Zhiyong;Zheng, Yuqian;Yu, Yanyang;Zhou, Changlin;Zhou, Quanlong;Zhang, Amin;Guo, Xueqian;Liu, Yuan;Wang, Wenli;Zhao, Shilong;Wang, Shengnan;Xu, Changhua;Liu, Yuan;Yang, Yan;Luo, Zisheng
关键词：
Lentinula edodes ; umami peptide; umami enhancing effect; biosensor; moleculardynamics simulation -
The ENaC taste receptor's perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis
作者：Li, Wen;Chen, Wanchao;Wu, Di;Zhang, Zhong;Liu, Peng;Li, Zhengpeng;Yang, Yan
关键词：
-
A novel directed enzymolysis strategy for the preparation of umami peptides in Stropharia rugosoannulata and its mechanism of taste perception
作者：Chen, Daoyou;Rong, Mingli;Yuan, Zhaoting;Miao, Tingwei;Song, Hucheng;Zhang, Lujia;Yang, Yan;Zhang, Chuanxi;Wei, Hao;Tang, Shuting;Jiang, Haiming
关键词：Stropharia rugosoannulata; Directed enzymolysis; Virtual screening; Umami peptide; Molecular simulation
