Structural Elucidation of a Polysaccharide from Flammulina velutipes and Its Lipid-Lowering and Immunomodulation Activities
文献类型： 外文期刊
作者： Jia, Wei 1 ; Wang, Wenhan 1 ; Yu, Dongsheng 1 ; Yu, Yangchao 3 ; Feng, Zhan 3 ; Li, Hewen 3 ; Zhang, Jingsong 1 ; Zhang, Henan 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Edible Fungi, Key Lab Edible Fungal Resources & Utilizat South, Minist Agr & Rural Affairs, Shanghai, Peoples R China
2.Natl Engn Res Ctr Edible Fungi, Natl R&D Ctr Edible Fungal Proc, Key Lab Agr Genet & Breeding Shanghai, Shanghai 201403, Peoples R China
3.Jiangsu Chinagreen Biotechnol Co Ltd, Suqian 223700, Peoples R China
关键词： Flammulina velutipes; polysaccharides; three-phase partitioning; structural characteristics; lipid-lowering activity; immunoregulatory activity
期刊名称：POLYMERS （ 影响因子：5.0； 五年影响因子：5.0 ）
ISSN：
年卷期： 2024 年 16 卷 5 期
页码：
收录情况： SCI
摘要： FVPT1, a novel heteropolysaccharide, was purified from the fruiting body of Flammulina velutipes using magnetic-field-assisted three-phase partitioning and gel permeation chromatography. The structure was characterized using monosaccharide composition and methylation analysis, infrared spectroscopy and nuclear magnetic resonance (NMR). The FVPT1 (similar to 1.64 x 10(4) Da) was composed of L-fucose, D-galactose, D-glucose and D-mannose at a molar ratio of 1.0:3.5:1.0:1.4. The polysaccharide repeating unit of FVPT1 was established with methylation analyses and NMR spectroscopy. Moreover, a zebrafish larva hyperlipidemia model test demonstrated that FVPT1 can show appreciable lipid-lowering effects. In addition, the FVPT1 exhibited remarkable immunoregulatory activity by increasing nitric oxide, interleukin (IL)-1 beta and IL-1 secretion in macrophages. Therefore, these results suggest that FVPT1 has the potential to be developed into a new immune or hypolipidemic health product.
- 相关文献
作者其他论文 更多>>
-
Comprehensive evaluation of Ganoderma lucidum fermented grains: Nutritional, functional, and safety aspects
作者：Yan, Mengqiu;Jiang, Xingyi;Liu, Yanfang;Zhang, Jingsong;Feng, Jie;Yan, Mengqiu;Jiang, Xingyi;Liu, Yanfang;Zhang, Jingsong;Feng, Jie;Jiang, Xingyi
关键词：Ganoderma lucidum; Grains; Solid-state fermentation; Nutritional value; Functional efficacy; Safety
-
Innovative submerged directed fermentation: Producing high molecular weight polysaccharides from Ganoderma lucidum
作者：Guo, Jia;Tang, Chenmin;Liu, Yanfang;Shi, Jia;Tang, Chuanhong;Feng, Jie;Zhang, Jingsong;Guo, Jia;Vunduk, Jovana
关键词：Ganoderma lucidum; Submerged fermentation; High molecular weight polysaccharide
-
Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis
作者：Xiong, Xinyi;Liu, Peng;Liu, Liping;Feng, Jie;Zhang, Jingsong;Yan, Mengqiu;Liu, Yanfang;Xiong, Xinyi;Xiong, Xinyi;Liu, Peng;Liu, Liping;Feng, Jie;Zhang, Jingsong;Yan, Mengqiu;Liu, Yanfang
关键词：Hyperuricemia; Lentinula edodes; Polysaccharide-protein complex; Gut microbiota; Gut-kidney axis
-
Fabrication of CMC-PVA-EGDE hydrogels for maintaining overall postharvest quality of small-size packaged straw mushroom
作者：Jin, Rui;Li, Xin-Lin;Sun, Lei;Sun, Wen-Jing;Cui, Feng-Jie;Jia, Wei;Li, Wen;Yang, Yan;Zhang, Jing-Song;Sun, Wen-Jing;Cui, Feng-Jie
关键词：Straw mushroom; Postharvest quality; Hydrogel packaging; Relative humidity; Respiration metabolism
-
Prospects and applications of efficient physical field processing technologies for polysaccharide extraction and quality improvement in edible mushrooms: A systematic review
作者：Zhang, Henan;Jiang, Fuchun;Tang, Chuanhong;Liu, Yanfang;Zhang, Jingsong
关键词：Edible mushrooms; Polysaccharides; Physical fields
-
Structural characterization of β-glucan in Hericium erinaceus pretreated by steam explosion and its effects on human gut microbiota in vitro
作者：Chen, Shuang;Ling, Bingqing;Liu, Xiaoyu;Liu, Liping;Feng, Jie;Zhang, Jingsong;Yang, Yan;Wu, Di;Liu, Yanfang;Chen, Shuang;Liu, Xiaoyu;Guo, Qingbin
关键词：beta-glucan; Hericium erinaceus; Structural characters; Composition of gut microbiota; Short chain fatty acids
-
Preparation, Structural Characterization, and In Vitro Modulation of the Gut Microbiota Activity of a Novel α-Glucan in Hericium erinaceus
作者：Chen, Shuang;Liu, Liping;Feng, Jie;Zhang, Jingsong;Geng, Jie;Wang, Jinyan;Yang, Yan;Wu, Di;Liu, Yanfang;Chen, Shuang;Guo, Qingbin
关键词：
Hericium erinaceus ; alpha-(1 -> 4)-glucan; structural characterization;in vitro digestion and fermentation; gut microbiota
