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Pharmacokinetics and tissue residues of enrofloxacin in the largemouth bass (Micropterus salmoides) after oral administration

文献类型： 外文期刊

作者： Shan, Qi 1 ; Wang, Jingxin 1 ; Zheng, Guangming 1 ; Zhu, Xinping 4 ; Yang, Yuanhao 5 ; Ma, Lisha 1 ; Zhao, Cheng 1 ; Li, 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Recreat Fisheries Res, Guangzhou 510380, Guangdong, Peoples R China

2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Lab Qual & Safety Risky Assessment Aquat Prod, Guangzhou, Guangdong, Peoples R China

3.Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China

4.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr, Key Lab Trop & Subtrop Fishery Resource Applicat, Guangzhou, Guangdong, Peoples R China

5.Fisheries Res Inst Shanxi Prov, Xian, Shaanxi, Peoples R China

关键词： ciprofloxacin; enrofloxacin; largemouth bass; pharmacokinetics; tissue residues; withdrawal time

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期：

页码：

收录情况： SCI

摘要： The study was carried out to evaluate the pharmacokinetic disposition of enrofloxacin (ENF) with a single dose of 20 mg/kg after oral administration in largemouth bass (Micropterus salmoides) at 28 degrees C. The concentrations of ENF and of its metabolite ciprofloxacin (CIP) in plasma, liver, and muscle plus skin in natural proportions were determined using HPLC. The concentration-time data for ENF in plasma were best described by a two-compartment open model. After oral administration, the maximum ENF concentration (C-max) of 10.99 mu g/ml was obtained at 0.60 hr. The absorption half-life (T-1/2Ka) of ENF was calculated to be 0.07 hr whereas the elimination half-life (T-1/2 beta) of the drug was 90.79 hr. The estimates of area under the plasma concentration-time curve (AUC) and apparent volume of distribution (Vd/F) were 1,185.73 mu g hr/ml and 2.21 L/kg, respectively. ENF residues were slowly depleted from the liver and muscle plus skin of largemouth bass with the T-1/2 beta of 124.73 and 115.14 hr, respectively. Very low levels of ciprofloxacin were detected in the plasma and tissues. A withdrawal time of 24 days was necessary to ensure that the residues of ENF + CIP in muscle plus skin were less than the maximal residue limit (MRL) of 100 mu g/kg established by the European Union.

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