您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Insights into the combined toxic impacts of phoxim and deltamethrin on the embryo-larval stage of zebrafish (Danio rerio)

文献类型： 外文期刊

作者： Lv, Lu 1 ; Gao, Zhongwen 2 ; Mao, Liangang 3 ; Liu, Xinju 1 ; Wang, Qiang 1 ; Shen, Weifeng 1 ; Wang, Yanhua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

2.Nankai Univ, Coll Chem, Res Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

3.Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China

关键词： Combined toxicity; Aquatic vertebrates; Biomarker; Synergetic impact

期刊名称：ENVIRONMENTAL SCIENCES EUROPE （ 影响因子：5.481； 五年影响因子：7.26 ）

ISSN： 2190-4707

年卷期： 2022 年 34 卷 1 期

页码：

收录情况： SCI

摘要： Background Pesticides are usually applied as mixtures, and their joint impacts can generate substantial toxicity to organisms. Although exposures to chemical pesticide mixtures make up most occurrences of pesticide exposures, minimal concern has been given to their combined toxicity and interplays to date. In the present study, endpoints of multiple levels were determined to examine the combined toxic impacts of phoxim and deltamethrin on zebrafish (Danio rerio). Results Our study showed that the LC50 values of phoxim obtained over a 96-h exposure period for D. rerio during different life stages ranged from 0.24 (0.12-0.33) to 3.39 (2.58-4.86) mu M, and those of deltamethrin ranged from 0.0041 (0.0031-0.0060) to 2.97 (1.56-4.69) mu M. Combinations of phoxim and deltamethrin displayed synergistic effects on zebrafish embryos. The activities of T-SOD, Cu/Zn-SOD, POD, and CarE varied dramatically under most administrations of phoxim, deltamethrin, and phoxim + deltamethrin combinations relative to the baseline value. Nine genes, namely, Mn-sod, Cu/Zn-sod, cas3, dio1, tsh, ER alpha, vtg1, cyp17, and crh, related to antioxidation, cell apoptosis, immunity, and the endocrine system were altered to a greater degree under the mixture administration compared with the individual administrations. Conclusions In summary, our current data offered a detailed insight into the combined toxic impacts of pesticide mixtures at various endpoints and over a wide range of concentrations. The results emphasized the necessity to consider the administration mixtures during the ecological risk assessment of pesticides.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台