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Biosynthetic Potential of a Novel Antarctic Actinobacterium Marisediminicola antarctica ZS314(T) Revealed by Genomic Data Mining and Pigment Characterization

文献类型： 外文期刊

作者： Liao, Li 1 ; Su, Shiyuan 1 ; Zhao, Bin 1 ; Fan, Chengqi 4 ; Zhang, Jin 1 ; Li, Huirong 1 ; Chen, Bo 1 ;

作者机构： 1.Polar Res Inst China, SOA Key Lab Polar Sci, 451 Jinqiao Rd, Shanghai 200136, Peoples R China

2.Shanghai Ocean Univ, Coll Marine Sci, Shanghai 201306, Peoples R China

3.East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China

4.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Minist Agr, Key Lab East China Sea & Ocean Fishery Resources, Shanghai 200090, Peoples R China

关键词： Marisediminicola; Antarctica; carotenoid; actinobacteria; natural products; gene cluster

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2019 年 17 卷 7 期

页码：

收录情况： SCI

摘要： Rare actinobacterial species are considered as potential resources of new natural products. Marisediminicola antarctica ZS314(T) is the only type strain of the novel actinobacterial genus Marisediminicola isolated from intertidal sediments in East Antarctica. The strain ZS314(T) was able to produce reddish orange pigments at low temperatures, showing characteristics of carotenoids. To understand the biosynthetic potential of this strain, the genome was completely sequenced for data mining. The complete genome had 3,352,609 base pairs (bp), much smaller than most genomes of actinomycetes. Five biosynthetic gene clusters (BGCs) were predicted in the genome, including a gene cluster responsible for the biosynthesis of C50 carotenoid, and four additional BGCs of unknown oligosaccharide, salinixanthin, alkylresorcinol derivatives, and NRPS (non-ribosomal peptide synthetase) or amino acid-derived compounds. Further experimental characterization indicated that the strain may produce C.p.450-like carotenoids, supporting the genomic data analysis. A new xanthorhodopsin gene was discovered along with the analysis of the salinixanthin biosynthetic gene cluster. Since little is known about this genus, this work improves our understanding of its biosynthetic potential and provides opportunities for further investigation of natural products and strategies for adaptation to the extreme Antarctic environment.

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