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Herbicide prometryn adversely affects the development and reproduction of Tigriopus japonicus by disturbing the ecdysone signal pathway and chitin metabolic pathway

文献类型： 外文期刊

作者： Wang, Dong 1 ; Yang, Guangxin 2 ; Ru, Shaoguo 1 ; Zhang, Zhenzhong 1 ; Li, Yuejiao 1 ; Wang, Jun 1 ;

作者机构： 1.Ocean Univ China, Coll Marine Life Sci, 5 Yushan Rd, Qingdao 266003, Shandong, Peoples R China

2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Lab Qual Safety & Proc Aquat Prod, Shanghai 200090, Peoples R China

关键词： Prometryn; Tigriopus japonicus; Life-history traits; 20-hydroxyecdysone; Chitin metabolic pathway

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN： 0166-445X

年卷期： 2023 年 254 卷

页码：

收录情况： SCI

摘要： Prometryn, a widely used triazine herbicide in agriculture and aquaculture, has been commonly detected in marine environments, but its effects on the marine copepod are unknown. In this study, marine copepod Tigriopus japonicus was chronically exposed to environmentally relevant concentrations of prometryn to investigate its impacts and potential mechanism of action. The results showed that 0.5, 5, and 50 mu g/L prometryn delayed the first spawning time and hatching time, reduced the fecundity, and inhibited the population growth rate. Moreover, exposure to 0.5, 5 and 50 mu g/L prometryn decreased food ingestion, the content of C and N elements, nutrient accumulation and body size, but increased the content of 20-hydroxyecdysone (20E). Transcriptome analysis showed that 50 mu g/L prometryn down-regulated 1431 genes, which were mainly enriched in lysosome pathway and chitin binding and cuticle construction process. The results of qRT-PCR showed that the expression of key genes involved in juvenile hormone synthesis and chitin metabolic pathways were also inhibited after prometryn exposure. Molecular docking revealed that prometryn could bind to ecdysone receptor (EcR) and UDP-N-acetylglucosamine pyrophosphorylase (UAP), components of the ecdysteroid nuclear receptor complex. Therefore, environmental relevant prometryn delayed the molting and development of T. japonicus by disrupting the ecdysone signal pathway and chitin metabolic pathway through binding to EcR and UAP. This study provides new insights into toxic effects and molecular mechanisms of prometryn on marine copepods.

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