Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1 alpha pathway
文献类型： 外文期刊
作者： Huang, Liang 1 ; Gao, Wei 1 ; He, Xuri 1 ; Yuan, Tong 1 ; Zhang, Huaqi 2 ; Zhang, Xiufen 1 ; Zheng, Wenxuan 1 ; Wu, Qilin 1 ; Liu, Ju 3 ; Wang, Wence 1 ; Yang, Lin 1 ; Zhu, Yongwen 1 ;
作者机构： 1.South China Agr Univ, State Key Lab Livestock & Poultry Breeding, Guangzhou 510000, Peoples R China
2.Tongren Polytech Coll, Tongren 554000, Peoples R China
3.Enping Long Ind Co Ltd, Jiangmen 529400, Enping, Peoples R China
关键词： Embryonic development; Maternal zinc; Mitochondrial function; Oxidative stress
期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN： 1674-9782
年卷期： 2023 年 14 卷 1 期
页码：
收录情况： SCI
摘要： Background Mitochondrial dysfunction induced by excessive mitochondrial reactive oxygen species (ROS) damages embryonic development and leads to growth arrest.Objective The purpose of this study is to elucidate whether maternal zinc (Zn) exert protective effect on oxidative stress targeting mitochondrial function using an avian model.Result In ovo injected tert-butyl hydroperoxide (BHP) increases (P < 0.05) hepatic mitochondrial ROS, malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), and decreases (P < 0.05) mitochondrial membrane potential (MMP), mitochondrial DNA (mtDNA) copy number and adenosine triphosphate (ATP) content, contributing to mitochondrial dysfunction. In vivo and in vitro studies revealed that Zn addition enhances (P < 0.05) ATP synthesis and metallothionein 4 (MT4) content and expression as well as alleviates (P < 0.05) the BHP-induced mitochondrial ROS generation, oxidative damage and dysfunction, exerting a protective effect on mitochondrial function by enhancing antioxidant capacity and upregulating the mRNA and protein expressions of Nrf2 and PGC-1a.Conclusions The present study provides a new way to protect offspring against oxidative damage by maternal Zn supplementation through the process of targeting mitochondria involving the activation of Nrf2/PGC-1a signaling.
- 相关文献
作者其他论文 更多>>
-
Evidence from an Avian Embryo Model that Zinc-Inducible MT4 Expression Protects Mitochondrial Function Against Oxidative Stress
作者：Li, Hao;Gao, Wei;Wang, Heng;Huang, Liang;Yuan, Tong;Zheng, Wenxuan;Wu, Qilin;Wang, Wence;Yang, Lin;Zhu, Yongwen;Zhang, Huaqi;Liu, Ju;Xu, Weihan
关键词：avian embryo model; metallothionein; mitochondrial function; oxidative stress; zinc
-
The developmental pattern related to fatty acid uptake and oxidation in the yolk sac membrane and jejunum during embryogenesis in Muscovy duck
作者：Li, Hao;Zhang, Xiufen;Wang, Xiaowen;Wu, Qilin;Zheng, Wenxuan;Ye, Hui;Wang, Wence;Yang, Lin;Zhu, Yongwen;Liu, Chuang;Wei, Shi;Zuo, Xin;Xiao, Wenquan;Zhu, Yongwen
关键词：growth curve; yolk sac membrane; jejunum; fatty acid; embryo
-
Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens
作者：Ruan, Dong;Chen, Zhilong;Gou, Zhongyong;Wang, Yibing;Zheng, Chuntian;Jiang, Shouqun;Wu, Shaowen;Huang, Wenjie;Yan, Shijuan;Fouad, Ahmed Mohamed;Zhu, Yongwen;Han, Yongquan
关键词：
-
A complete mitochondrial genome for fragrant Chinese rosewood (Dalbergia odorifera, Fabaceae) with comparative analyses of genome structure and intergenomic sequence transfers
作者：Hong, Zhou;Zhang, Ningnan;Yang, Zengjiang;Xu, Daping;Liao, Xuezhu;Zhu, Weidong;Gao, Wei;Wu, Zhiqiang;Ye, Yuanjun;Gao, Wei;Sharbrough, Joel;Tembrock, Luke R.
关键词：Plant mitochondrial genome; Chloroplast genome; Horizontal gene transfer; Repetitive DNA; Phylogeny; Threatened species
-
Effect of Maternal Marginal Zinc Deficiency on Development, Redox Status, and Gene Expression Related to Oxidation and Apoptosis in an Avian Embryo Model
作者：Gao, Wei;Huang, Liang;Zhang, Xiufen;Wang, Wence;Zheng, Yaohui;Yang, Lin;Zhu, Yongwen;Ma, Xinyan;Geng, Wei;Liu, Chuang;Wei, Shi
关键词：
-
Ochratoxin A induces liver inflammation: involvement of intestinal microbiota
作者：Wang, Wence;Zhai, Shuangshuang;Xia, Yaoyao;Wang, Hao;Zhu, Yongwen;Ye, Hui;Ren, Wenkai;Yang, Lin;Ruan, Dong;Zhou, Ting;Zhang, Hongfu;Zhang, Minhong
关键词：Ochratoxin A; Intestinal microbiota; LPS; Liver inflammation; Fecal microbiota transplantation
-
Role of Quzhou Fructus Aurantii Extract in Preventing and Treating Acute Lung Injury and Inflammation
作者：Li, Lili;Yang, Lin;Xuan, Yaoxian;Li, Lili;Zhang, Sheng;Xin, Yanfei;Xie, Feng;Yang, Lin;Chen, Zhiqin;Chen, Hao;Liu, Fang;Xuan, Yaoxian;You, Zhenqiang;Sun, Junying
关键词：
