Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1 alpha pathway
文献类型： 外文期刊
作者： Huang, Liang 1 ; Gao, Wei 1 ; He, Xuri 1 ; Yuan, Tong 1 ; Zhang, Huaqi 2 ; Zhang, Xiufen 1 ; Zheng, Wenxuan 1 ; Wu, Qilin 1 ; Liu, Ju 3 ; Wang, Wence 1 ; Yang, Lin 1 ; Zhu, Yongwen 1 ;
作者机构： 1.South China Agr Univ, State Key Lab Livestock & Poultry Breeding, Guangzhou 510000, Peoples R China
2.Tongren Polytech Coll, Tongren 554000, Peoples R China
3.Enping Long Ind Co Ltd, Jiangmen 529400, Enping, Peoples R China
关键词： Embryonic development; Maternal zinc; Mitochondrial function; Oxidative stress
期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：7.0； 五年影响因子：7.3 ）
ISSN： 1674-9782
年卷期： 2023 年 14 卷 1 期
页码：
收录情况： SCI
摘要： Background Mitochondrial dysfunction induced by excessive mitochondrial reactive oxygen species (ROS) damages embryonic development and leads to growth arrest.Objective The purpose of this study is to elucidate whether maternal zinc (Zn) exert protective effect on oxidative stress targeting mitochondrial function using an avian model.Result In ovo injected tert-butyl hydroperoxide (BHP) increases (P < 0.05) hepatic mitochondrial ROS, malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), and decreases (P < 0.05) mitochondrial membrane potential (MMP), mitochondrial DNA (mtDNA) copy number and adenosine triphosphate (ATP) content, contributing to mitochondrial dysfunction. In vivo and in vitro studies revealed that Zn addition enhances (P < 0.05) ATP synthesis and metallothionein 4 (MT4) content and expression as well as alleviates (P < 0.05) the BHP-induced mitochondrial ROS generation, oxidative damage and dysfunction, exerting a protective effect on mitochondrial function by enhancing antioxidant capacity and upregulating the mRNA and protein expressions of Nrf2 and PGC-1a.Conclusions The present study provides a new way to protect offspring against oxidative damage by maternal Zn supplementation through the process of targeting mitochondria involving the activation of Nrf2/PGC-1a signaling.
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