Heterogeneity of extracellular vesicles in porcine myoblasts regulates adipocyte differentiation
文献类型： 外文期刊
作者： Qin, Mengran 1 ; Xing, Lipeng 1 ; Wen, Shulei 1 ; Luo, Junyi 1 ; Sun, Jiajie 1 ; Chen, Ting 1 ; Zhang, Yongliang 1 ; Xi, Qianyun 1 ;
作者机构： 1.South China Agr Univ, Guangdong Prov Key Lab Anim Nutr Control, State Key Lab Livestock & Poultry Breeding, Natl Engn Res Ctr Breeding Swine Ind,Coll Anim Sci, 483 Wushan Rd, Guangzhou 510642, Peoples R China
2.Tianjin Univ, Tianjin Hosp, Tianjin 300211, Peoples R China
3.Tianjin Orthoped Inst, Tianjin 300050, Peoples R China
4.Tianjin Key Lab Orthoped Biomech & Med Engn, Tianjin 300050, Peoples R China
关键词： Skeletal muscle stem cells; Porcine; sEV; Heterogeneity; Adipocytes
期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）
ISSN： 2045-2322
年卷期： 2024 年 14 卷 1 期
页码：
收录情况： SCI
摘要： The interactions between myogenic cells and adipocytes play an important role in improving carcass traits and the efficiency of energy utilization. However, there are few reports about the interaction between them mediated by small extracellular vesicles (sEV). In this study, sEV derived from porcine primary skeletal muscle stem cells (MuSCs) was found to be involved in the inhibition of porcine primary adipocyte viability, triglyceride content, Oil Red O enrichment and the expression of adipogenic genes. When the MuSCs were treated with insulin (INS) and oleic acid (OA), the effects of their secreted sEVs on adipose precursor cells were reversed, suggesting that the signaling effects of sEV are related to their own heterogeneity. Further by component heterogeneity analysis, miR-146a-5p was found to be enriched in sEVs of MuSCs and to regulate and suppress adipogenesis through its heterogeneity. This study provides an important mechanism and molecular target for small extracellular vesicles to regulate the interaction between muscle and adipose tissue and improve carcass traits at the intercellular level.
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