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Bioaccumulation of manganese and its effects on oxidative stress and immune response in juvenile groupers (Epinephelus moara female x E. lanceolatus male)

文献类型： 外文期刊

作者： Wang, Xi 1 ; Gao, Xiao-Qiang 1 ; Wang, Xin-Yi 1 ; Fang, Ying-Ying 1 ; Xu, Liang 1 ; Zhao, Kui-Feng 3 ; Huang, Bin 1 ; Liu, Bao-Liang 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao Key Lab Marine Fish Breeding & Biotechnol, Key Lab Sustainable Dev Marine Fisheries,Minist A, Qingdao 266071, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

3.Yuhai Hongqi Ocean Engn Co LTD, Rizhao 276800, Peoples R China

关键词： Manganese; Bioaccumulation; Oxidative stress; Immune response; Epinephelus moara female x E; lanceolatus male

期刊名称：CHEMOSPHERE （ 影响因子：8.943； 五年影响因子：8.52 ）

ISSN： 0045-6535

年卷期： 2022 年 297 卷

页码：

收录情况： SCI

摘要： We evaluated the effects of Mn in juvenile Yunlong groupers (Epinephelus moara female x E. lanceolatus male). The groupers were exposed to Mn2+ (0, 0.5, 1, 2, and 4 mg/L) for 30 days after which they were assessed. The results indicate the accumulation of Mn in fish depended on dose and time. Mn2+ accumulation in tissues occurred in the following order: liver > gills > intestine > muscle. The concentrations of SOD and CAT in the fish significantly increased after 10 and 20 days of treatment with 4 mg/L Mn2+ but decreased after 30 days. Similarly, GSH and GPx levels increased after 10 days of exposure to 2 and 4 mg/L Mn2+ but decreased after 20 and 30 days of exposure. Additionally, malondialdehyde levels significantly increased after exposing the fish to 2 and 4 mg/L Mn2+ for 10, 20, and 30 days. In addition, liver HSP70 and HSP90 levels significantly increased at days 20 and 30 in all fish exposed to Mn2+. In addition, when Mn2+ concentration was 1, 2, and 4 mg/L, liver C3 and C4 levels were significantly increased after 10, 20, and 30 days. Conversely, the levels of LZM and IgM significantly decreased. Mn2+ also significantly upregulated the expression of genes associated with immunity (tlr3, tnf-alpha, il1 beta, and il-6) in the fish, which suggests that it induces immunotoxicity by altering the immune response. Overall, the findings showed that Mn2+ can disrupt grouper health by bioaccumulating in the fish and subsequently inducing oxidative stress and immune responses. These results can help elucidate the mechanism by which manganese induces toxicity in marine fish. Additionally, they provide a new perspective regarding the detrimental effects of heavy metals in fish.

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