中国水产科学研究院机构知识库

Environmentally relevant concentrations of Mn²⁺ disrupts the endocrine regulation of growth in juvenile Yunlong groupers (Epinephelus moara♀xEpinephelus lanceolatus♂)

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文献类型：外文期刊

作者： Wang, Xi ¹ ; Liu, Bao-Liang ¹ ; Zhang, Xian-Hong ¹ ; Cao, Shu-Quan ¹ ; Gao, Xiao-Qiang ¹ ; Zhao, Kui-Feng ³ ; Zhang, Chuan-Xin ⁴ ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Shandong, Peoples R China

2.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China

3.Yuhai Hongqi Ocean Engn Co LTD, Rizhao 276800, Peoples R China

4.Rizhao Wanbao Aquat Grp Corp, Rizhao 276800, Peoples R China

关键词： Manganese; GH/IGF axis; HPT axis; Neurotransmitter; Epinephelus.moara female xE.lanceolatus male

期刊名称：AQUATIC TOXICOLOGY （影响因子：4.5；五年影响因子：5.2 ）

ISSN： 0166-445X

年卷期： 2023 年 264 卷

页码：

收录情况： SCI

摘要： Even though manganese is a bioelement essential for metabolism, excessive manganese levels in water can be detrimental to fish development and growth. Therefore, the aim of this study was to evaluate the effects of Mn2+ (0, 0.5,1, 2, and 4 mgL-1) exposure for 30 d on the growth performance, growth hormone/insulin-like growth factor (GH/IGF) axis, hypothalamic-pituitary-thyroid (HPT) axis, and monoaminergic neurotransmitters of Epinephelus moara female xEpinephelus lanceolatus male(Yunlong grouper). Compared with the control and low Mn(2+)concentration groups of (0.5 and 1 mgL-1), the high concentration of Mn2+ (4 mgL-1) significantly reduced body weight (BW), body length (BL), weight gain rate (WGR), and specific growth rate (SGR), increased the feed coefficient rate (FCR) and mortality of Yunlong groupers (P < 0.05). Further, the levels of GH and IGF, along with the expression of ghra and ghrb were significantly reduced after exposure to 2 and 4 mgL-1 Mn(2+)for 30 d, whereas the expression of sst5 was significantly up-regulated after exposure to 2 and 4 mgL-1 Mn(2+)for 20 and 30 days. Moreover, Mn(2+)exposure increased thyroid hormone (T3) and thyroid stimulating hormone (TSH) contents, accompanied by increased mRNA levels of dio1 and dio2, however, the T4 level was decreased. Finally, dopamine (DA) and serotonin (5-HT) levels significantly decreased after long-term exposure to higher concentrations of Mn2+, and the levels their metabolites changed as well, suggesting that the synthesis and metabolism of DA and 5-HT were affected. Accordingly, changes in the GH/IGF and HPT axes-related parameters may be the cause of growth inhibition in juvenile groupers under Mn2+ exposure, indicating that the relationship between endocrine disorder and growth inhibition should not be ignored.

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Environmentally relevant concentrations of Mn2+ disrupts the endocrine regulation of growth in juvenile Yunlong groupers (Epinephelus moara♀xEpinephelus lanceolatus♂)

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Environmentally relevant concentrations of Mn²⁺ disrupts the endocrine regulation of growth in juvenile Yunlong groupers (Epinephelus moara♀xEpinephelus lanceolatus♂)

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