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Comparative transcriptome analysis of the molecular mechanism underlying the golden red colour in mutant Taiwanese loach

文献类型： 外文期刊

作者： Huang, Zhihui 1 ; Ma, Benhe 3 ; Guo, Xiaoli 1 ; Wang, Haihua 3 ; Ma, Aijun 1 ; Sun, Zhibin 1 ; Wang, Qingmin 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Shandong Key Lab Marine Fisheries Biotechnol & Ge, Qingdao Key Lab Marine Fish Breeding & Biotechnol, No 106 Nanjing Rd, Qingdao 266071, Peoples R China

2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China

3.Jiangxi Fisheries Res Inst, Expt Stn Lake Fishery Resources & Environm, Minist Agr & Rural Affairs, No 1099 Fudayou Rd, Nanchang 330039, Jiangxi, Peoples R China

4.Nanchang Key Lab Special Aquact Breeding & Health, No 1099 Fudayou Rd, Nanchang 330039, Jiangxi, Peoples R China

关键词： Taiwanese loach (Paramisgurnus dabryanus ssp. Taiwan); RNA-Seq; Albinism; Melanogenesis; Lipid metabolism

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2021 年 543 卷

页码：

收录情况： SCI

摘要： Taiwanese loach (Paramisgurnus dabryanus ssp. Taiwan) have mutant phenotypes with golden-pink eyes and golden-red body colour without any blotches. We consider this colour variation comparable to albinism reported in other species. However, the molecular mechanism underlying these mutations is unknown. In the present study, we conducted a comparative analysis of transcripts from the skin of wild-type and mutant fish. A total of 6516 differentially expressed genes (DEGs) were identified, including 3317 (50.9%) upregulated unigenes and 3199 (49.1%) downregulated unigenes in mutant individuals. Additional annotation comparing known pigmentation genes and KEGG pathway analysis indicated that the melanogenesis pathway is the key pathway regulating pigment synthesis. Oca2, slc45a2 and mc1r were identified as potential genes associated with albinism. Analysis of the top 10 KEGG pathways revealed that some DEGs were liked to lipid metabolism, such fish skin transcriptome results have not been reported previously. The fatty acid composition of fish skin was analysed by gas chromatography, and the results were consistent with the RNA-Seq analysis. We propose that cells possess intrinsic mechanisms to dampen inflammation and avoid excessive damage, resulting in albino mutants. This is the first report of a mutant-type (golden-red albinism) Taiwanese loach with golden-red skin colour from fish farms in China. The findings provide a basis for studying the molecular mechanism underlying the abnormalities of pigmentation, and will facilitate the future genetic selection and breeding of Taiwanese loach in aquaculture.

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