Tea (Camellia sinensis) Ameliorates Hyperuricemia via Uric Acid Metabolic Pathways and Gut Microbiota
文献类型： 外文期刊
作者： Wu, Dan 1 ; Chen, Ruohong 2 ; Li, Qiuhua 2 ; Lai, Xingfei 2 ; Sun, Lingli 2 ; Zhang, Zhenbiao 2 ; Wen, Shuai 2 ; Sun, Shili 2 ; Cao, Fanrong 1 ;
作者机构： 1.South China Agr Univ, Coll Hort, Guangzhou 510640, Peoples R China
2.Guangdong Acad Agr Sci, Guangdong Prov Key Lab Tea Plant Resources Innova, Res Inst, Guangzhou 510640, Peoples R China
关键词： Camellia sinensis; six types of tea; hyperuricemia; uric acid metabolism disorder; oxidative stress; gut microbiota
期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）
ISSN：
年卷期： 2022 年 14 卷 13 期
页码：
收录情况： SCI
摘要： Hyperuricemia (HUA) is a metabolic disease that threatens human health. Tea is a healthy beverage with an abundance of benefits. This study revealed the uric acid-lowering efficacy of six types of tea water extracts (TWEs) on HUA in mice. The results revealed that under the intervention of TWEs, the expression of XDH, a key enzyme that produces uric acid, was significantly downregulated in the liver. TWE treatment significantly upregulated the expression of uric acid secretion transporters ABCG2, OAT1, and OAT3, and downregulated the expression of uric acid reabsorption transporter URAT1 in the kidney. Furthermore, HUA-induced oxidative stress could be alleviated by upregulating the Nrf2/HO-1 pathway. The intervention of TWEs also significantly upregulated the expression of the intestinal ABCG2 protein. On the other hand, TWE intervention could significantly upregulate the expression of intestinal ABCG2 and alleviate HUA by modulating the gut microbiota. Taken together, tea can comprehensively regulate uric acid metabolism in HUA mice. Interestingly, we found that the degree of fermentation of tea was negatively correlated with the uric acid-lowering effect. The current study indicated that tea consumption may have a mitigating effect on the HUA population and provided a basis for further research on the efficacy of tea on the dosage and mechanism of uric acid-lowering effects in humans.
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