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Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59

文献类型： 外文期刊

作者： Xu, Yitong 1 ; Zhang, Huifeng 2 ; Zhang, Ying 1 ; Ma, Jiutong 1 ; Jia, Qiong 1 ;

作者机构： 1.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

2.Jilin Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Changchun 130033, Peoples R China

关键词： Epitope imprinting; Host-guest interaction; Tannic acid; CD59

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.0； 五年影响因子：3.6 ）

ISSN： 0021-9673

年卷期： 2025 年 1755 卷

页码：

收录情况： SCI

摘要： The detection of CD59 is of great clinical importance since it is an important glycoprotein that can serve as a biomarker related to kinds of cancers. In this work, we prepared host-guest interaction based oriented epitope molecularly imprinted polymer (hg-EMIP) for the immobilization of CD59 N-terminal epitopes. Cucurbit[7]uril (CB[7]) and l-phenylalanine (L-phe) were employed as the host and guest; and tannic acid (TA) with abundant hydroxyl groups and diethylenetriamine (DETA) were chosen as the functional monomer and crosslinking agent, respectively. The obtained hg-EMIP can specifically recognize CD59 with the adsorption capacity of 88.2 mg/g and imprinting factor of 5.63, and possesses high reusability. The hg-EMIP-based method possesses a wide linear range (1 ng/mL - 1 mu g/mL) and low limit of detection (0.44 ng/mL), and can be successfully used for the detection of CD59 in human serum sample. This study provides a scheme for the preparation of host-guest based epitope molecularly imprinted polymers for helping to identify potential disease biomarkers efficiently.

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