文献类型： 外文期刊
作者： Niu, Yujia 1 ; Yu, Wancong 2 ; Kou, Xiaohong 1 ; Wu, Shuqi 1 ; Liu, Mengyi 1 ; Chen, Chenlong 1 ; Ji, Jiaxin 1 ; Shao, Ying 1 ; Xue, Zhaohui 1 ;
作者机构： 1.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China
2.Tianjin Acad Agr Sci, Biotechnol Res Inst, Tianjin 300384, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.4； 五年影响因子：6.1 ）
ISSN： 2042-6496
年卷期： 2024 年 15 卷 24 期
页码：
收录情况： SCI
摘要： Obesity, a significant health crisis, arises from an imbalance between energy intake and expenditure. Enhancing appetite regulation has garnered substantial attention from researchers as a novel and effective strategy for weight management. The melanocortin system, situated in the hypothalamus, is recognized as a critical node in the regulation of appetite. It integrates long-term and short-term hormone signals from the periphery as well as nutrients, forming a complex network of interacting feedback mechanisms with the gut-brain axis, significantly contributing to the regulation of energy homeostasis. Appetite regulation by bioactive compounds has been a focus of intensive research due to their favorable safety profiles and easy accessibility. These bioactive compounds, derived from a variety of plant and animal sources, modulate the melanocortin system and influence appetite and energy homeostasis through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota. Here, we review the anatomy, function, and receptors of the melanocortin system, outline the long-term and short-term regulatory hormones that act on the melanocortin system, and discuss the bioactive compounds and their mechanisms of action that exert a regulatory effect on appetite by targeting the melanocortin system. This review contributes to a better understanding of how bioactive compounds regulate appetite via the melanocortin system, thereby providing nutritional references for citizens' dietary preferences.
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