ApoE/NOS3 Knockout Mice as a Novel Cardiovascular Disease Model of Hypertension and Atherosclerosis
文献类型： 外文期刊
作者： Liu, Ke 1 ; Chen, Bangzhu 2 ; Zeng, Fanwen 1 ; Wang, Gang 2 ; Wu, Xin 2 ; Liu, Yueshu 2 ; Li, Guiling 2 ; Yan, Jiarong 2 ; Zhang, Shouquan 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Agro Anim Genom & Mol Bree, Guangzhou 510642, Peoples R China
2.Guangdong Med Lab Anim Ctr, Foshan 528248, Peoples R China
关键词： double gene knockout; ApoE; NOS3; atherosclerosis; hypertension; effect assessment
期刊名称：GENES （ 影响因子：4.141； 五年影响因子：4.474 ）
ISSN：
年卷期： 2022 年 13 卷 11 期
页码：
收录情况： SCI
摘要： Hypertension is an independent risk factor for atherosclerosis. However, few models of hypertensive atherosclerosis have been established in medical research. In this study, we crossed the ApoE knockout (ApoE-KO; ApoE(-/-)) atherosclerotic mouse model with the NOS3 knockout (NOS3-KO; NOS3(-/-)) hypertensive mouse model to establish an ApoE/NOS3 double knockout (ApoE/NOS3-KO; ApoE/NOS3(-/-)) hypertensive atherosclerosis mouse model. We found that ApoE/NOS3(-/-) mice reproduced normally, had a blood pressure of 133.00 +/- 3.85 mmHg, and developed hypertensive fundus retinopathy and hypertensive nephropathy. In addition, serum total cholesterol (TC) and low-density lipoprotein (LDL) levels in the blood were abnormally elevated, steatosis was observed in the liver cells, and atherosclerotic lesions were observed in the aortic vessels in ApoE/NOS3(-/-) adult mice. In conclusion, ApoE/NOS3(-/-) adult mice are a satisfactory model of hypertension and atherosclerosis and can be utilized for studies on cardiovascular diseases.
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