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Preparation of zinc phthalocyanine-loaded amphiphilic phosphonium chitosan nanomicelles for enhancement of photodynamic therapy efficacy

文献类型： 外文期刊

作者： Yang, Ziming 1 ; Li, Puwang 2 ; Chen, Yu 1 ; Dong, Enming 2 ; Feng, Zhipan 1 ; He, Zuyu 2 ; Zhou, Chuang 2 ; Wang, Chao 2 ;

作者机构： 1.Beijing Inst Technol, Beijing 100081, Peoples R China

2.Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524091, Guangdong, Peoples R China

关键词： Chitosan; Phosphonium; Zinc phthalocyanine; Nanomicelle; Photodynamic therapy

期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.268； 五年影响因子：4.957 ）

ISSN： 0927-7765

年卷期： 2021 年 202 卷

页码：

收录情况： SCI

摘要： To increase the solubility and the encapsulation of zinc phthalocyanine (ZnPc) photosensitizer for photodynamic therapy (PDT), a positively charged amphiphilic phosphonium chitosan nanomicelle with multi-benzene structure was developed, and its application to PDT was explored. N-acetyl-L-phenylalanine-(4-carboxybutyl) triphenylphosphonium bromide chitosan (CTPB-CS-NAP), a chitosan derivative with tunable amphiphilicity, was synthesized first. ZnPc was encapsulated in CTPB-CS-NAP at the critical micelle concentration (CMC) of 4.898 mg/L by a hydrophobic self-assembly method to form ZnPc-loaded nanomicelles (ZnPc@CTPB-CS-NAP). The method gives the highest encapsulation efficiency and drug loading of 89.4 % and 22.3 %, respectively. ZnPc@CTPB-CS-NAP is stably dispersed in aqueous solution and shows the average particle size of 103 +/- 5 nm. PDT experiments suggest the phototoxicity of ZnPc@CTPB-CS-NAP is much higher than that of ZnPc, but no obvious dark cytotoxicity is observed. Our study has provided a new strategy for improving the photodynamic therapy efficacy of hydrophobic photosensitizer by the encapsulation with chitosan derivative carriers.

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