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Tissue-Specific Toxicity in Common Carp (Cyprinus carpio) Caused by Combined Exposure to Triphenyltin and Norfloxacin

文献类型： 外文期刊

作者： Liu, Yiwei 1 ; Li, Luoxin 2 ; Zhang, Siqi 1 ; Yin, Minghao 1 ; Li, Tengzhou 1 ; Zeng, Bianhao 1 ; Liu, Ling 1 ; Li, Ping 1 ; Li, Zhihua 1 ;

作者机构： 1.Shandong Univ, Marine Coll, Weihai 264209, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

关键词： organotin compound; quinolone antibiotics; common carp; joint toxicity

期刊名称：FISHES （ 影响因子：2.4； 五年影响因子：2.4 ）

ISSN：

年卷期： 2024 年 9 卷 10 期

页码：

收录情况： SCI

摘要： Triphenyltin (TPT) is a commonly encountered organotin compound known for its endocrine-disrupting properties; it frequently interacts with antibiotics in aquatic environments. In this study, common carp (Cyprinus carpio) (17.43 +/- 4.34 g, 11.84 +/- 0.88 cm) were chosen as the experimental organisms. According to the environmental concentration in the heavily polluted area, the control group and the experimental groups were exposed for 21 days to the following treatments: 1 mu g/L TPT, 1 mg/L NOR, and a combination of 1 mu g/L TPT plus 1 mg/L NOR. The investigation examined the individual and combined toxicities of TPT and norfloxacin (NOR) on the gill, liver, and gut tissues of common carp in highly polluted areas. The findings revealed tissue-specific variations in 1L-1 beta enzyme activity; specifically, 1L-1 beta enzyme activity exhibited a significant reduction in liver tissue under both NOR exposure and combined exposure, indicating that high concentrations of NOR had the most pronounced impact on the immune system of liver tissue. Furthermore, the gene expression levels of IL-1 beta, Lysozyme-C, NKA, and CPT1 in the liver, intestinal, and gill tissues showed differences after exposure. In addition, TPT exerted the most significant effect on intestinal tissue, followed by the liver and gill tissues. Interestingly, when TPT and NOR were exposed together, the toxic effects on all tissues were reduced, suggesting the existence of antagonistic effects.

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