您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Female zebrafish ( Danio rerio) ) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring

文献类型： 外文期刊

作者： Zhang, Chunyun 1 ; Li, Luoxin 2 ; Alava, Juan Jose 3 ; Yan, Zebang 1 ; Chen, Peng 4 ; Gul, Yasmeen 5 ; Wang, Lixin 1 ; Xiong, Dongmei 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

3.Univ British Columbia, Inst Oceans & Fisheries, Ocean Pollut Res Unit, AERL, 2202 Main Mall, Vancouver, BC V6T 1Z4, Canada

4.Xinjiang Uygur Autonomous Reg Fisheries Res Inst, Urumqi 830000, Xinjiang, Peoples R China

5.Govt Coll Women Univ, Dept Zool, Faisalabad 38860, Pakistan

关键词： PS-NPs; Maternal exposure; Reproductive dysfunction; Zebrafish

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.1； 五年影响因子：4.4 ）

ISSN： 0166-445X

年卷期： 2024 年 273 卷

页码：

收录情况： SCI

摘要： Nanoplastics (NPs) have been commonly detected in aquatic ecosystems, and their negative effects on aquatic organisms have raised concerns in the scientific community and general public. The acute toxicity, neurotoxicity, and metabolic toxicity induced by NPs on fishes have been reported by many studies, although less attention has been focused on how mother exposed to NPs affected their offspring in aquatic organisms. Here, female zebrafish (F0) were exposed to 0, 200 and 2000 mu g/L polystyrene nanoplastics (PS-NPs) for 42 d, with their offspring (F1) reared in clear water until sexual maturity. The results showed that PS-NPs were detected in various organs of F0 and F1. PS-NPs exposure significantly decreased gonadal 17-estradiol (E2), while increasing testosterone (T) contents. Lower levels of cyp19a1a, lhr and er alpha expressions in the 2000 mu g/L group were consistent with a reduced number of mature oocytes (MO), but an increase in perinucleolar oocytes (PO). Interestingly, the expression of vtg was only up-regulated by 200 mu g/L PS-NPs. After exposure, the egg production was dramatically reduced, but the hatching rate and heartbeat of F1 embryos from treated females were significantly higher than those observed in females from the control group. Maternal PS-NPs exposure significantly decreased the E2 and T levels in F1 adults, while PS-NPs exposure significantly up-regulated the sox9a but down-regulated the foxl2a in F1 larvae of 30 days post fertilization (dpf). This study showed that PS-NPs caused reproductive toxicity by changing the hypothalamic-pituitary-gonadal (HPG) axis-related genes, impairing the reproductive capacity of female zebrafish, affecting the development and disrupting the endocrine function of F1. These results suggested that PS-NPs had adverse effects on fish reproductive system both in the directly exposed generation and in their unexposed offspring.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台