Herpes simplex virus type I glycoprotein L evades host antiviral innate immunity by abrogating the nuclear translocation of phosphorylated NF-kappa B sub-unit p65
文献类型： 外文期刊
作者： Li, Zhaolong 1 ; Feng, Zhihua 2 ; Fang, Zhou 2 ; Chen, Jianghua 2 ; Chen, Wengzhi 2 ; Liang, Wangwang 2 ; Chen, Qi 2 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou, Fujian, Peoples R China
2.Fujian Normal Univ, Coll Life Sci, Fujian Key Lab Innate Immune Biol, Qishan Campus, Fuzhou, Fujian, Peoples R China
关键词： HSV-1; GL; NF-kappa B; p65; evasion
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）
ISSN：
年卷期： 2023 年 14 卷
页码：
收录情况： SCI
摘要： Nuclear factor (NF)-kappa B plays an important role in the innate immune response by inducing antiviral genes' expression. However, the herpes simplex virus 1 (HSV-1) virus has developed multiple ways to interfere with NF-kappa B activity to escape the host antiviral response. Here, we found that HSV-1 envelope glycoprotein L(gL) markedly inhibits interferon (IFN) production and its downstream antiviral genes. Our results showed that ectopic expression of gL inhibited IFN-beta promoter activation, and decreased IFN-beta production, the expression of IFN-stimulated genes (ISGs), and inhibited immunologic stimulant (poly I:C) induced activation of IFN signaling pathway. Depletion of gL by short interfering RNA (siRNA) significantly upregulated IFN-beta and ISG production. Further study showed that the N-terminus of the gL bound to the Rel homology domain (RHD) of the p65 and concealed the nuclear localization signal of p65, thereby impeding the translocation of phosphorylated p65 to the nucleus. In summary, our findings indicated that the N-terminal of HSV-1 gL contributes to immune invasion by inhibiting the nuclear translocation of p65.
- 相关文献
作者其他论文 更多>>
-
Duck compound probiotics fermented diet alters the growth performance by shaping the gut morphology, microbiota and metabolism
作者：Li, Zhaolong;Li, Cuiting;Lin, Fengqiang;Yan, Lu;Wu, Huini;Zhou, Haiou;Guo, Qing;Huang, Yu;Lin, Binbin;Xie, Bilin;Xu, Yijuan;Lin, Zhimin;Liu, Wenjin
关键词：fermented diet; duck; compound probiotics; growth performance
-
Generation and Characterization of Recombinant Pseudorabies Virus Delivering African Swine Fever Virus CD2v and p54
作者：Wei, Jianhui;Liu, Chuancheng;He, Xinyan;Abbas, Bilal;Chen, Qi;Feng, Zhihua;Li, Zhaolong
关键词：African swine fever virus; pseudorabies virus; CD2v; p54; vaccine
-
Inhibitory mechanisms of decoy receptor 3 in cecal ligation and puncture-induced sepsis
作者：Su, Jingqian;Chen, Wenzhi;Zhou, Fen;Tong, Zhiyong;Wu, Shun;Guan, Biyun;Feng, Zhihua;Chen, Kunsen;Chen, Qi;Chen, Wenzhi;Li, Rui;Ye, Zhen;Zhang, Yichao;Lin, Ben;Chen, Long;Yu, Xing
关键词：gut microbiota; decoy receptor 3; sepsis; anti-inflammatory
-
Effect of Mechanical Damage in Green-Making Process on Aroma of Rougui Tea
作者：Lin, Fuming;Wu, Huini;Gao, Chenxi;Wang, Zhihui;Sun, Weijiang;Lin, Fuming;Huang, Yan;Li, Zhaolong;Lin, Xiying;Yu, Wenquan
关键词：Wuyi Rock Tea; transcriptomes; proteomics; volatile organic compounds; green-making process; gas chromatography
-
Lactobacillus plantarum supernatant inhibits growth of Riemerella anatipestifer and mediates intestinal antimicrobial defense in Muscovy ducks
作者：Li, Zhaolong;Guo, Qing;Lin, Fengqiang;Li, Cuiting;Yan, Lu;Zhou, Haiou;Huang, Yu;Huang, Yaping;Lin, Binbin;Xie, Bilin;Lin, Zhimin
关键词：Riemerella anatipestifer; Lactobacillus plantarum supernatant; inhibition; antimicrobial defense
-
Alterations in intestinal microbiota and metabolites in individuals with Down syndrome and their correlation with inflammation and behavior disorders in mice
作者：Cai, Shaoli;Lin, Jinxin;Liu, Songnian;Feng, Zhihua;Zhang, Yangfan;Chen, Qi;Cai, Shaoli;Lin, Jinxin;Liu, Songnian;Feng, Zhihua;Zhang, Yangfan;Chen, Qi;Cai, Shaoli;Lin, Jinxin;Feng, Zhihua;Zhang, Yangfan;Zhang, Yanding;Huang, Jianzhong;Chen, Qi;Li, Zhaolong
关键词：Down syndrome; cytokines; intestinal microbiota; metabolomics; inflammation
-
Effects of a traditional Chinese medicine formula containing the Coix seed and Lotus seed on the intestinal morphology and microbiota of local piglets
作者：Li, Zhaolong;Lin, Zhongning;Lu, Zheng;Ying, Zhaoyang
关键词：Traditional Chinese Medicine Formula; Piglets; Gut microbiota; pH; Villus; Production performance
