Dendrobium officinale polysaccharides alleviated DSS-induced ulcerative colitis in mice through remolding gut microbiota to regulate purine metabolism
文献类型： 外文期刊
作者： Li, Jingrui 1 ; Tao, Wenyang 1 ; Zhou, Wanyi 1 ; Xing, Jianrong 1 ; Luo, Mengfan 1 ; Lu, Shengmin 1 ; Yang, Ying 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310021, Peoples R China
关键词： Dendrobium officinale; Polysaccharides; Ulcerative colitis; Gut microbiota; Metabolomics
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：3.8； 五年影响因子：4.6 ）
ISSN： 1756-4646
年卷期： 2024 年 119 卷
页码：
收录情况： SCI
摘要： Dendrobium officinale (DO) has no side effects and has been used for centuries to treat gastrointestinal diseases in China. Polysaccharides are the primary components of DO (referred to as DOP). In this study, leaf polysaccharides (DOPY) and stem polysaccharides (DOPJ) were extracted to investigate the protective effect on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice and explore its mechanisms of action through analyzing the intestinal microbiota and metabolites in cecum contents. The results showed that DOP reduced the disease activity index (DAI), improved colonic pathology, and protected the integrity of the intestinal barrier (Occludin and Muc2) in UC mice. 16S rRNA sequencing suggested that DOP increased the abundance of beneficial bacteria ( Turicibacter and Romboutsia ) and reduced the abundance of harmful bacteria ( Escherichia-Shigella and Parvibacter ). Metabolomic analysis revealed that DOP regulated purine metabolism in the intestine, thereby maintaining intestinal mucosal immune homeostasis. These findings suggested that DOP exerted promising protection against DSS-induced ulcerative mice through remolding gut microbiota to regulate purine metabolism.
- 相关文献
作者其他论文 更多>>
-
Unveiling the molecular mechanisms of Dendrobium officinale polysaccharides on intestinal immunity: An integrated study of network molecular and in vivo experiments
作者：Yang, Chenchen;Li, Jingrui;Luo, Mengfan;Zhou, Wanyi;Xing, Jianrong;Yang, Ying;Tao, Wenyang;Wang, Lu;Rao, Wenjia
关键词：Dendrobium officinale polysaccharides; Intestinal immunity; Network pharmacology; Molecular docking and simulation; Mice model
-
Dendrobium officinale leaf polysaccharide has a dual effect of alleviating the syndromes of immunosuppressed mice and modulating immune system of normal mice
作者：Li, Jingrui;Tao, Wenyang;Zhou, Wanyi;Xing, Jianrong;Luo, Mengfan;Lu, Shengmin;Yang, Ying
关键词：Dendrobium officinale leaf; Polysaccharide; Immune system; Gut microbiota; Cyclophosphamide
-
Effects of Dityrosine on Lactic Acid Metabolism in Mice Gastrocnemius Muscle During Endurance Exercise via the Oxidative Stress-Induced Mitochondria Damage
作者：Xia, Qiudong;Lan, Jinchi;Pan, Yuxiang;Wang, Yuxin;Song, Tianyuan;Gu, Zhenyu;Ding, Yin-Yi;Yang, Ying;Tian, Xu;Chen, Longjun
关键词：dityrosine; lactate acid metabolism; enduranceexercise; oxidative stress; mitochondria damage
-
Differential impacts of porous starch versus its octenyl succinic anhydride-modified counterpart on naringin encapsulation, solubilization, and in vitro release
作者：Wang, Lu;Lu, Shengmin;Liu, Yinying;Lu, Hanyu;Zheng, Meiyu;Zhou, Zhongjing;Cao, Feng;Yang, Ying;Liu, Yinying;Lu, Hanyu;Fang, Zhongxiang
关键词：Modified starches; Naringin encapsulation and solubilization; In vitro release
-
The characterization of the pectin/alginate nanoparticle for encapsulation of hydroxypropyl-β-cyclodextrin-complexed naringin and its effects on cellular uptake and oxidative stress in Caco-2 cells
作者：Zheng, Meiyu;Zhang, Wenjuan;Lu, Shengmin
关键词：Naringin; Hydroxypropyl-beta-cyclodextrin; Nanoparticle; Pectin; Antioxidant activity
-
Differential effects of enzymatically modified Ougan (Citrus Suavissima Hort. ex Tanaka) peel pectins extracted with different methods on inhibiting the proliferation of Hela cells
作者：Du, Shuangning;Tao, Wenyang;Lu, Shengmin;Du, Shuangning;Wang, Yangguang;Lu, Shengmin
关键词：Suavissima Hort. ex Tanaka) peel pectins; Extraction method; Cell viability
-
Whole-Genome Sequencing of Lactiplantibacillus plantarum YY-112 and Investigation of Its Immune-Modulating Abilities In Vivo
作者：Luo, Mengfan;Guo, Yuxing;Zhou, Wanyi;Tao, Wenyang;Xing, Jianrong;Li, Jingrui;Yang, Ying
关键词：Lactiplantibacillus plantarum; genome; cyclophosphamide; immunity; intestinal microbiota
