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Hemiactinomycin, an undescribed intermediate of actinomycin biosynthesis from an actinomycetes strain Streptomyces antibioticus H41-55

文献类型： 外文期刊

作者： Liu, Ting 1 ; Xu, Tianqi 1 ; Hu, Chen 3 ; Sun, Dayuan 4 ; Zhou, Guangxiong 1 ;

作者机构： 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China

2.Nanchang Med Coll, Nanchang, Jiangxi, Peoples R China

3.Gannan Healthcare Vocat Coll, Ganzhou, Jiangxi, Peoples R China

4.Guangdong Acad Agr Sci, Plant Protect Res Inst, Guangzhou, Guangdong, Peoples R China

5.Key Lab New Tech Plant Protect Guangdong, Guangzhou, Guangdong, Peoples R China

关键词： Actinomycetes; hemiactinomycin; anti-inflammatory; biosynthesis

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.488； 五年影响因子：2.51 ）

ISSN： 1478-6419

年卷期：

页码：

收录情况： SCI

摘要： Hemiactinomycin (1), an intermediate derivative of actinomycin biosynthesis, together with three known actinomycins (2-4) , were isolated from the ethanolic extract of Streptomyces antibioticus H41-55 fermentation mycelium by using various column chromatography. The structure of the derivative was established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. In addition, the anti-inflammatory activities of all the isolates were tested. The derivative (1) showed inhibiting NO release activities in LPS-induced RAW 264.7 macrophages with the IC50 values of 15.41 +/- 0.66 mu M.

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