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Whole-genome analysis of stress resistance-related genes in Listeria monocytogenes

文献类型： 外文期刊

作者： Dou, Xin 1 ; Liu, Yangtai 1 ; Li, Zhuosi 1 ; Panagou, Efstathios Z. 2 ; Zhang, Hui 3 ; Zhu, Huajian 1 ; Dong, Qingli 1 ;

作者机构： 1.Univ Shanghai Sci & Technol, 516 Jun Gong Rd, Shanghai 200093, Peoples R China

2.Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Microbiol & Biotechnol Foods, Athens, Greece

3.Jiangsu Acad Agr Sci, Nanjing, Peoples R China

关键词： Listeria monocytogenes; Whole genome sequencing; Stress resistance; Risk; Strain typing

期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：6.6； 五年影响因子：6.9 ）

ISSN： 0023-6438

年卷期： 2024 年 213 卷

页码：

收录情况： SCI

摘要： Listeria monocytogenes is a crucial foodborne pathogen with significant public health implications. This study analyzed whole-genome sequences (WGS) of L. monocytogenes strains from public databases, examining associations between resistance genes, lineage, strain type, isolation source, and geography. Results revealed that after eliminating duplicates and strains with incomplete WGS, a total of 316 strains were deemed suitable for subsequent analyses. Within these strains, lineages I and II were extensively distributed, predominantly isolated from clinical and food sources. 56.65% of these strains fell into seven major Clonal Complexes (CC), identified by Multilocus Sequence Typing (MLST), correlating significantly with isolation information. Analysis of 46 resistance-related genes showed a high consistency of resistance genes in the same type of strains, hinting at a potential causal chain of 'food-food environment-evolution of L. monocytogenes'. Moreover, the standard strains exhibit similar gene carriage rates as the sample strains, with multiple variations observed in acid-resistance genes. In conclusion, through a comprehensive analysis of the L. monocytogenes genome sequences, this study deepens our understanding of the differences and associations between its lineage, strain typing, isolation sources, geographical distribution, and resistance genes, thereby providing a scientific basis for formulating more effective prevention and control strategies.

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