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Mechanisms of Adipose Tissue Metabolism in Naturally Grazing Sheep at Different Growth Stages: Insights from mRNA and miRNA Profiles

文献类型： 外文期刊

作者： He, Xige 1 ; Han, Yunfei 3 ; Chen, Lu 3 ; Yun, Yueying 5 ; Huang, Yajuan 3 ; Borjigin, Gerelt 3 ; Nashun, Buhe 1 ;

作者机构： 1.Inner Mongolia Univ, Inner Mongolia Key Lab Mol Regulat Cell, Hohhot 010070, Peoples R China

2.Inner Mongolia Univ, Sch Life Sci, State Key Lab Reprod Regulat & Breeding Grassland, Hohhot 010040, Peoples R China

3.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Hohhot 010018, Peoples R China

4.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010031, Peoples R China

5.Inner Mongolia Univ Sci & Technol, Sch Life Sci & Technol, Baotou 014010, Peoples R China

关键词： fat deposition; miRNA; mRNA; Ovis aries; subcutaneous adipose tissue

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 7 期

页码：

收录情况： SCI

摘要： Adipose tissue metabolism plays a crucial role in sheep meat quality and the optimization of adipose tissue utilization. To reveal the molecular mechanisms of adipose tissue metabolism during growth in naturally grazing sheep, we investigated the mRNA and miRNA profiles in subcutaneous adipose tissue (SAT) from naturally grazing Sunit sheep at 6, 18, and 30 months of age (Mth-6, Mth-18, and Mth-30). We identified 927 differentially expressed (DE) genes and 134 DE miRNAs in the SAT of sheep at different growth stages. Specifically, the expressions of ACACA, FASN, DGAT2, GPAM, SCD, ELOVL6, HSD17B12, TECR, PKM, TKT, PCK1, CD44, and THBS2S genes were significantly upregulated in Mth-18 and Mth-30 compared to that in Mth-6. These genes promoted fatty acid synthesis, triglyceride synthesis, gluconeogenesis, and extracellular matrix-receptor interaction and decreased glycolysis, leading to increased adipocyte proliferation and fat deposition. Notably, our findings suggested that the reduced activity of the AMPK signaling pathway may be regulated by CAMKK2 and PP2A during sheep growth. Furthermore, our results revealed several DE miRNAs, mml-miR-320b, chi-miR-1388-3p, bta-miR-6715, oar-miR-143, and miR-424, that potentially influence fat metabolism. Overall, this study provides a theoretical basis and new insights into the molecular mechanisms of adipose tissue metabolism during growth in naturally grazing sheep.

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