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Metagenomic Sequencing Identified Specific Bacteriophage Signature Discriminating between Healthy and Diarrheal Neonatal Piglets

文献类型： 外文期刊

作者： Wang, Zhenyu 1 ; Li, Jingjing 1 ; Ma, Lingyan 3 ; Liu, Xiangdong 1 ; Wei, Hong 1 ; Xiao, Yingping 3 ; Tao, Shiyu 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China

2.China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

关键词： diarrhea; virus; metagenome; neonatal; E.~coli

期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）

ISSN：

年卷期： 2023 年 15 卷 7 期

页码：

收录情况： SCI

摘要： Neonatal diarrhea is one of the most severe diseases in human beings and pigs, leading to high mortality and growth faltering. Gut microbiome-related studies mostly focus on the relationship between bacteria and neonatal diarrhea onset, and no research study has investigated the role of the gut virome in neonatal diarrhea. Here, using metagenomic sequencing, we characterized the fecal viral community of diarrheal and healthy neonatal piglets. We found that the viral community of diarrheal piglets showed higher individual heterogeneity and elevated abundance of Myoviridae. By predicting the bacterial host of the identified viral genomes, phages infecting Proteobacteria, especially E. coli, were the dominant taxa in neonatal diarrheal piglets. Consistent with this, the antibiotic resistance gene of E. coli origin was also enriched in neonatal diarrheal piglets. Finally, we established a random forest model to accurately discriminate between neonatal diarrheal piglets and healthy controls and identified genus E. coli- and genus listeria-infecting bacteriophages, including psa and C5 viruses, as key biomarkers. In conclusion, we provide the first glance of viral community and function characteristics in diarrheal and healthy neonatal piglets. These findings expand our understanding of the relationship among phages, bacteria and diarrhea, and may facilitate the development of therapeutics for the prevention and treatment of neonatal diarrhea.

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