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Flavonoids from Ougan ( Citrus suavissima Hort. ex Tanaka) peel exert hypoglycemic potency through inhibiting insulin resistance in HepG2 cells and regulating gut microbiota in diabetic mice

文献类型： 外文期刊

作者： Zhou, Hongyan 1 ; Lu, Shengmin 1 ; Zheng, Meiyu 1 ; Ouyang, Xiaokun 2 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Food Sci, State Key Lab Managing Biot & Chem Threats Qual &, Zhejiang Key Lab Intelligent Food Logist & Proc,Mi, Hangzhou 310021, Peoples R China

2.Zhejiang Ocean Univ, Sch Food & Pharm, Zhoushan 316022, Peoples R China

关键词： Ougan ( Citrus suavissima Hort. Ex Tanaka); Flavonoids; Hypoglycemic; Insulin resistance-HepG2 cell; Gut microbiota; Diabetic mice

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.0； 五年影响因子：4.9 ）

ISSN： 1756-4646

年卷期： 2024 年 123 卷

页码：

收录情况： SCI

摘要： To fully and value-addedly utilize the citrus peel resource, flavonoids were extracted and purified from peel powder of Ougan ( Citrus suavissima Hort. ex Tanaka) using an ultrasonic assisted ethanol solution extraction method and AB-8 macroporous resin purification. The obtained flavonoid extract from peel of Ougan (FEPO) was used for the hypoglycemic experiments in vitro and in vivo on glucose consumption in insulin resistance model HepG2 cells and streptozotocin induced diabetes model mice. A significant reduction of glucose consumption in the model cells while a significant increase in the treated were found in a dose-dependent manner, compared to 5.2241 +/- 0.2201 mmol/L of the normal cells (P < 0.05). When the FEPO concentration was 80 mu g/mL, the cell glucose consumption was 4.4055 +/- 0.1772 mmol/L. Compared with those in the model group (diabetic mice), the fasting blood glucose in the FEPO intervened mice was significantly decreased (P < 0.05). FEPO intervention caused decreased levels of TC, TG, LDL-C, and increased HDL-C and insulin contents in the serums as well as ameliorative histopathology of the liver, kidney, and pancreas in diabetic mice. FEPO improved the gut microbiota structure of diabetic mouse by regulating its composition, especially significantly increasing the relative abundance of Lactobacillus, Ileibacterium, unclassified_f_Lachnospiracea, Romboutsia, norank_f_Muribaculaceae, Faecalibaculum and Coriobacteriaceae_UCG-002 ( P < 0.05), while decreasing that of norank_f_norank_o_Clostridia_UCG-014, Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas. In conclusion, FEPO had good hypoglycemic efficacies both in vitro and in vivo as well as gut microbiota regulating effect.

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