Whole-body adipose tissue multi-omic analyses in sheep reveal molecular mechanisms underlying local adaptation to extreme environments
文献类型： 外文期刊
作者： Xu, Ya-Xi 1 ; Wang, Bo 1 ; Jing, Jia-Nan 1 ; Ma, Rui 1 ; Luo, Yan-Hui 1 ; Li, Xin 1 ; Yan, Ze 1 ; Liu, Ya-Jing 1 ; Gao, Lei 2 ; Ren, Yan-Ling 3 ; Li, Meng-Hua 1 ; Lv, Feng-Hua 1 ;
作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China
2.Xinjiang Acad Agr & Reclamat Sci, Inst Anim Husb & Vet Med, Shihezi, Peoples R China
3.Shandong Binzhou Acad Anim Sci & Vet Med, Binzhou, Peoples R China
期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：5.9； 五年影响因子：6.3 ）
ISSN：
年卷期： 2023 年 6 卷 1 期
页码：
收录情况： SCI
摘要： The fat tail of sheep is an important organ that has evolved to adapt to extreme environments. However, the genetic mechanisms underlying the fat tail phenotype remain poorly understood. Here, we characterize transcriptome and lipidome profiles and morphological changes in 250 adipose tissues from two thin-tailed and three fat-tailed sheep populations in summer and winter. We implement whole-genome selective sweep tests to identify genetic variants related to fat-tails. We identify a set of functional genes that show differential expression in the tail fat of fat-tailed and thin-tailed sheep in summer and winter. These genes are significantly enriched in pathways, such as lipid metabolism, extracellular matrix (ECM) remodeling, molecular transport, and inflammatory response. In contrast to thin-tailed sheep, tail fat from fat-tailed sheep show slighter changes in adipocyte size, ECM remodeling, and lipid metabolism, and had less inflammation in response to seasonal changes, indicating improved homeostasis. Whole-genome selective sweep tests identify genes involved in preadipocyte commitment (e.g., BMP2, PDGFD) and terminal adipogenic differentiation (e.g., VEGFA), which could contribute to enhanced adipocyte hyperplasia. Altogether, we establish a model of regulatory networks regulating adipose homeostasis in sheep tails. These findings improve our understanding of how adipose homeostasis is maintained, in response to extreme environments in animals. Survival in extreme environments and adaptations during seasonal shifts require specialized metabolic programing. A multi-omic analysis of how regulatory networks impact adipose homeostasis in sheep tails provides insight for how these animals survive extreme environments.
- 相关文献
作者其他论文 更多>>
-
Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds
作者：Peng, Weifeng;Shi, Wanlu;Liu, Zi;Guo, Xinyu;Zhang, Yunxia;Li, Bing;Li, Guoyin;Cao, Jingya;Yang, Mingsheng;Zhang, Yiyuan;Gao, Lei
关键词：Goat; Selection pressure; Environment; Signatures of Selection; SNP
-
The Transmission Effect Test of China's Rotation Mechanism on the Cotton Reserve Market
作者：Li, Xiaoxiao;Wang, Bo;Sun, Lingyan;Zhu, Honghui;Lv, Ning;Zhang, Jiaqi;Lv, Ning
关键词：rotation mechanism on the cotton reserve market (RMRC); transmission effect; simultaneous equation; supply chain
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
-
Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci
作者：Lv, Feng-Hua;Luo, Ling-Yun;Lu, Ran;Chen, Jian-Fei;Wang, Jian-Kui;Deng, Xue-Mei;Dehghani-Qanatqestani, Mostafa;Li, Meng-Hua;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Cao, Yin-Hong;Salehian-Dehkordi, Hosein;Liu, Guang-Jian;Liu, Ming-Jun;Li, Wen-Rong;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Zhou, Ping;Wang, Xin-Hua;Shen, Min;Gao, Lei;Yang, Jing-Quan;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Wan, Peng-Cheng;Zhang, Yun-Sheng;Pi, Wen-Hui;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Wang, Yu-Tao;Li, Jin-Quan;Hehua, Eer;Liu, Yong-Gang;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Charati, Hadi;Rushdi, Hossam E.;Nosrati, Maryam;Stepanek, Ondrej;Olsaker, Ingrid;Curik, Ino;Gorkhali, Neena A.;Paiva, Samuel R.;Caetano, Alexandre R.;Ciani, Elena;Amills, Marcel;Amills, Marcel;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Mwacharo, Joram M.;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Periasamy, Kathiravan;Johansson, Anna M.;Hallsson, Jon H.;Kantanen, Juha;Coltman, David W.;Bruford, Michael W.;Bruford, Michael W.;Lenstra, Johannes A.
关键词：whole-genome sequences; genetic diversity; adaptive introgression; genetic selection; agronomic traits; migration
-
Genomic analyses of wild argali, domestic sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation
作者：Li, Xin;Luo, Ling-Yun;Yan, Ze;Mo, Dong-Xin;Wan, Xing;Lv, Feng-Hua;Yang, Ji;Xu, Ya-Xi;Deng, Juan;Zhu, Qiang-Hui;Li, Meng-Hua;Li, Xin;Zhu, Qiang-Hui;Xie, Xing-Long;Xu, Song-Song;Li, Xin;Zhu, Qiang-Hui;Xie, Xing-Long;Xu, Song-Song;He, San-Gang;Li, Wen-Rong;Liu, Chen-Xi;Peng, Xin-Rong;Han, Bin;Li, Zhong-Hui;Chen, Lei;Liu, Ming-Jun;Deng, Juan;Han, Jian-Lin;Han, Jian-Lin;Ding, Xue-Zhi;Dingkao, Renqing;Chu, Yue-Feng;Wu, Jin-Yan;Wang, Li-Min;Zhou, Ping;Wang, Li-Min;Zhou, Ping
关键词：
-
Whole-Genome Selective Scans Detect Genes Associated With Important Phenotypic Traits in Sheep (Ovis aries)
作者：Xu, Song-Song;Lyu, Fenghua;Xu, Song-Song;Gao, Lei;Shen, Min
关键词：artificial selection; genome-wide SNPs; sheep; phenotypic traits; genetic improvement
-
Combined Transcriptome and Proteome Analysis of Anthers of AL-type Cytoplasmic Male Sterile Line and Its Maintainer Line Reveals New Insights into Mechanism of Male Sterility in Common Wheat
作者：Hao, Miaomiao;Yang, Wenlong;Li, Tingdong;Shoaib, Muhammad;Sun, Jiazhu;Liu, Dongcheng;Li, Xin;Zhang, Aimin;Hao, Miaomiao;Li, Tingdong;Shoaib, Muhammad;Yang, Wenlong;Nie, Yingbin;Tian, Xiaoming
关键词：AL-type cytoplasmic male sterility; AL18A; transport; anthers development genes; wheat
