ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels
文献类型： 外文期刊
作者： Li, Jianrui 1 ; Gu, Wei 1 ; Yang, Zhijia 1 ; Chen, Jian 1 ; Yi, Fei 1 ; Li, Tong 1 ; Li, Jingrui 4 ; Zhou, Yue 5 ; Guo, Yan 4 ; Song, Weibin 1 ; Lai, Jinsheng 1 ; Zhao, Haiming 1 ;
作者机构： 1.China Agr Univ, Natl Maize Improvement Ctr, Frontiers Sci Ctr Mol Design Breeding, Dept Plant Genet & Breeding,State Key Lab Maize Bi, Beijing, Peoples R China
2.Shanghai Acad Agr Sci, CYMMIT China Specialty Maize Res Ctr, Shanghai Engn Res Ctr Specialty Maize, Crop Breeding & Cultivat Res Inst,Shanghai Key Lab, Shanghai, Peoples R China
3.China Agr Univ, Coll Agron & Biotechnol, Minist Educ, Engn Res Ctr Plant Growth Regulator, Beijing, Peoples R China
4.China Agr Univ, Coll Biol Sci, State Key Lab Plant Environm Resilience, Beijing, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Adv Agr Sci, State Key Lab Prot & Plant Gene Res, Beijing, Peoples R China
关键词： Elongator complex; histone acetylation; transcriptional elongation; kernel development; maize
期刊名称：PLANT BIOTECHNOLOGY JOURNAL （ 影响因子：13.8； 五年影响因子：13.2 ）
ISSN： 1467-7644
年卷期： 2024 年 22 卷 5 期
页码：
收录情况： SCI
摘要： The Elongator complex was originally identified as an interactor of hyperphosphorylated RNA polymerase II (RNAPII) in yeast and has histone acetyltransferase (HAT) activity. However, the genome-wide regulatory roles of Elongator on transcriptional elongation and histone acetylation remain unclear. We characterized a maize miniature seed mutant, mn7 and map-based cloning revealed that Mn7 encodes one of the subunits of the Elongator complex, ZmELP1. ZmELP1 deficiency causes marked reductions in the kernel size and weight. Molecular analyses showed that ZmELP1 interacts with ZmELP3, which is required for H3K14 acetylation (H3K14ac), and Elongator complex subunits interact with RNA polymerase II (RNAPII) C-terminal domain (CTD). Genome-wide analyses indicated that loss of ZmELP1 leads to a significant decrease in the deposition of H3K14ac and the CTD of phosphorylated RNAPII on Ser2 (Ser2P). These chromatin changes positively correlate with global transcriptomic changes. ZmELP1 mutation alters the expression of genes involved in transcriptional regulation and kernel development. We also showed that the decrease of Ser2P depends on the deposition of Elongator complex-mediated H3K14ac. Taken together, our results reveal an important role of ZmELP1 in the H3K14ac-dependent transcriptional elongation, which is critical for kernel development.
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