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Effects of Cadmium on Liver Function and Its Metabolomics Profile in the Guizhou Black Goat

文献类型： 外文期刊

作者： Li, Yuanfeng 1 ; Shen, Xiaoyun 1 ;

作者机构： 1.Southwest Univ Sci & Technol, Coll Life Sci & Engn, Mianyang 621010, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China

关键词： metabolomics; cadmium; goat; liver

期刊名称：METABOLITES （ 影响因子：4.1； 五年影响因子：4.5 ）

ISSN：

年卷期： 2023 年 13 卷 2 期

页码：

收录情况： SCI

摘要： Cadmium (Cd) is a toxic heavy metal, which will lead to ecosystem contamination, threatening the life of grazing animals. Goats are an important grazing animal biomarker to evaluate Cd toxicity, but the effect of short-term and high-concentration Cd toxicity on goat liver function and its latent mechanism is still unclear. A total of ten male Guizhou black goats were randomly divided into two groups: CON group, sterilized tap water (no CdCl2), and Cd group (20 mg Cd center dot kg(-1)center dot BW, CdCl2 center dot 2.5H(2)O). The test lasted for 30 days. In this study, we found that Cd poisoning in drinking water affected significantly the distribution of Cd in the goat offal and tissues, and damaged the goat's immune function of the liver. With a metabolomics approach, 59 metabolites were identified. Metabolomics analysis suggested that Cd affected lipid and amino acid metabolism of the goat liver. Collectively, our results confirmed the effect of Cd on liver function and liver metabolism, and provided insights on the molecular basis for early warnings of Cd poisoning in goats.

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