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Autophagy: Are Amino Acid Signals Dependent on the mTORC1 Pathway or Independent?

文献类型： 外文期刊

作者： Jin, Chenglong 1 ; Zhu, Min 5 ; Ye, Jinling 1 ; Song, Zhiwen 5 ; Zheng, Chuntian 1 ; Chen, Wei 1 ;

作者机构： 1.State Key Lab Swine & Poultry Breeding Ind, Guangzhou 510640, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510640, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Nutr & Feed Sci South China, Guangzhou 510640, Peoples R China

4.Guangdong Prov Key Lab Anim Breeding & Nutr, Guangzhou 510640, Peoples R China

5.Guizhou Univ, Key Lab Anim Genet Breeding & Reprod Plateau Mt Re, Minist Educ, Coll Anim Sci, Guiyang 550025, Peoples R China

关键词： amino acid; autophagy; molecular mechanism; mTORC1

期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 1467-3037

年卷期： 2024 年 46 卷 8 期

页码：

收录情况： SCI

摘要： Autophagy is a kind of "self-eating" phenomenon that is ubiquitous in eukaryotic cells. It mainly manifests in the damaged proteins or organelles in the cell being wrapped and transported by the autophagosome to the lysosome for degradation. Many factors cause autophagy in cells, and the mechanism of nutrient-deficiency-induced autophagy has been a research focus. It has been reported that amino-acid-deficiency-induced cellular autophagy is mainly mediated through the mammalian rapamycin target protein complex 1 (mTORC1) signaling pathway. In addition, some researchers also found that non-mTORC1 signaling pathways also regulate autophagy, and the mechanism of autophagy occurrence induced by the deficiency of different amino acids is not precisely the same. Therefore, this review aims to summarize the process of various amino acids regulating cell autophagy and provide a narrative review on the molecular mechanism of amino acids regulating autophagy.

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