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Regenerative field effect transistor biosensor for in vivo monitoring of dopamine in fish brains

文献类型： 外文期刊

作者： Liu, Na 1 ; Xiang, Xueping 2 ; Fu, Lei 4 ; Cao, Qiang 1 ; Huang, Rong 1 ; Liu, Huan 1 ; Han, Gang 1 ; Wu, Lidong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Key Lab Control Qual & Safety Aquat Prod, Beijing 100141, Peoples R China

2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol, Hangzhou 310009, Peoples R China

3.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Bion Sensing & Intelligence Ctr, Shenzhen 518055, Peoples R China

关键词： Fe3O4@AuNPs; FET biosensor; Magnetic field; Dopamine; Fish brain

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.618； 五年影响因子：9.323 ）

ISSN： 0956-5663

年卷期： 2021 年 188 卷

页码：

收录情况： SCI

摘要： The detection of dopamine, one of the neurotransmitters in cerebral physiology, is critical in studying brain activities and understanding brain functions. However, regenerative biosensor for monitoring dopamine in the progress of physiological and pathological events is still challenging, due to lack of the platform for repetitive online detection-regeneration cycle. Herein, we have developed a regenerated field effect transistor (FET) combined with in vivo monitoring system. In this biosensor, gold-coated magnetic nanoparticles (Fe3O4@AuNPs) acts as a regenerated recognition unit for dopamine. Just by simple removal of a permanent magnet, dopamine on the biosensor interface are catalyzed by tyrosinase, thus achieving the regeneration of the biosensor. As a result, this FET biosensor not only reveals high sensitivity and selectivity, but also exhibits excellent stability after 15 regeneration processing. This biosensor is capable of monitor dopamine with a linear range between 1 mu mol L-1 and 120 mu mol L-1 and low detection limit (DL) of 3.3 nmol L-1. Then, the platform has been successfully applied in dopamine analysis in fish brain under global cerebral cortical neurons. This FET biosensor is the first to on-line and remote control the sensitivity and DL by permanent magnet. It opens the door to reusable, inexpensive and large-scale productions.

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