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CRAMdb: a comprehensive database for composition and roles of microbiome in animals

文献类型： 外文期刊

作者： Lei, Bingbing 1 ; Xu, Yueren 1 ; Lei, Yunjiao 1 ; Li, Cunyuan 1 ; Zhou, Ping 2 ; Wang, Limin 2 ; Yang, Qing 4 ; Li, Xiaoyue 1 ; Li, Fulin 1 ; Liu, Chuyang 1 ; Cui, Chaowen 1 ; Chen, Tong 3 ; Ni, Wei 1 ; Hu, Shengwei 1 ;

作者机构： 1.Shihezi Univ, Coll Life Sci, Shihezi 832003, Xinjiang, Peoples R China

2.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832003, Xinjiang, Peoples R China

3.China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Breeding Base Daodi Herbs, Beijing, Peoples R China

4.Minist Water Resources & Chinese Acad Sci, Key Lab Ecol Impacts Hydraul Projects & Restorat, Inst Hydroecol, Minist Water Resources, Wuhan 430079, Peoples R China

5.Shihezi Univ, Coll Sci, Key Lab Ecol Corps Oasis City & Mt Basin Syst, Shihezi 832000, Xinjiang, Peoples R China

期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：19.16； 五年影响因子：17.21 ）

ISSN： 0305-1048

年卷期：

页码：

收录情况： SCI

摘要： CRAMdb (a database for composition and roles of animal microbiome) is a comprehensive resource of curated and consistently annotated metagenomes for non-human animals. It focuses on the composition and roles of the microbiome in various animal species. The main goal of the CRAMdb is to facilitate the reuse of animal metagenomic data, and enable cross-host and cross-phenotype comparisons. To this end, we consistently annotated microbiomes (including 16S, 18S, ITS andmetagenomics sequencing data) of 516 animals from 475 projects spanning 43 phenotype pairs to construct the database that is equipped with 9430 bacteria, 278 archaea, 2216 fungi and 458 viruses. CRAMdb provides two main contents: microbiome composition data, illustrating the landscape of the microbiota (bacteria, archaea, fungi, and viruses) in various animal species, and microbiome association data, revealing the relationships between the microbiota and various phenotypes across different animal species. More importantly, users can quickly compare the composition of themicrobiota of interest cross-host or body site and the associated taxa that differ between phenotype pairs cross-host or cross-phenotype. CRAMdb is freely available at (http://www.ehbio.com/ CRAMdb).

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