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Tumor microbiota affects the efficacy of tea polyphenols therapy in breast tumor

文献类型： 外文期刊

作者： Tang, Xiaoyu 1 ; Dong, Sashuang 3 ; Zheng, Yubin 1 ; Zhao, Xiaoya 1 ; Sun, Yuan 1 ; Fang, Xiang 3 ; Ma, Jingyun 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

2.Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Peoples R China

3.South China Agr Univ, Coll Food Sci, Wushan Rd 483, Guangzhou 510642, Guangdong, Peoples R China

4.Shaoguan Univ, Guangdong Prov Key Lab Utilizat & Conservat Food &, Shaoguan 512000, Peoples R China

关键词： Tumor microbiota; Tea polyphenols; Breast tumor; Co -administration

期刊名称：FOOD BIOSCIENCE （ 影响因子：4.8； 五年影响因子：5.1 ）

ISSN： 2212-4292

年卷期： 2024 年 61 卷

页码：

收录情况： SCI

摘要： The therapeutic efficacy of tea polyphenols (TP) has been demonstrated in various tumor types, and research has indicated its potential role in modulating the intestinal microbiota. However, the impact of it on tumor microbiota remains uncertain. The research aimed to investigate how TP treatment affects microorganisms in breast tumors (4T1) and explore their potential influence on the TP's therapeutic efficacy. The TP significantly inhibited the growth of 4T1 tumors, and DOX-TP significantly enhanced the efficacy of TP against the tumors, whereas DOX alone did not show similar effects. The results of 16 S rDNA sequences indicated that Herbaspirillum, Herminiimonas, Stenotrophomonas exhibited a remarkable increase (regulation rate >= 99.72% and the abundance up-regulation by 7.91%, 5.17% and 5.77%, respectively), transitioning from absence to presence in the TP group to the DOX-TP group. Conversely, Halomonas, ZOR0006, Hydrogenophilus, Rhodococcus, Vibrio were significantly decreased (regulation rate >= 99.91% and the abundance down-regulation by 3.16%, 2.78%, 3.15%, 12.92% and 16.03%, respectively) after DOX-TP treatment, resulting in a shift from presence to absence. Compared to the TP group, DOX-TP group demonstrated enhanced infiltration of CD4+ T and CD8+ T cells, while exhibiting significantly elevated expression levels of IL-2, IFN-alpha, IFN-gamma and TNF-alpha. Additionally, Rhodococcus and Halomonas were observed to be negatively correlated with IFN-alpha expression. The co-administration of TP and antibiotics further modified the tumor microbiota composition, influencing the tumor immune microenvironment. The study demonstrated that DOX-TP can enhance TP's anticancer effect by modulating the tumor microbiota.

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