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Response signatures of intestinal microbiota and gene transcription of the tiger grouper Epinephelus fuscoguttatus to nervous necrosis virus infection

文献类型： 外文期刊

作者： Yang, Yukai 1 ; Lin, Heizhao 1 ; Xing, Yifu 1 ; Wen, Jiufu 1 ; Fang, Wei 1 ; Zhang, Jiasong 1 ; Duan, Yafei 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Guangdong Prov Key Lab Fishery Ecol & Environm,Mi, Guangzhou 510300, Peoples R China

2.Chinese Acad Fishery Sci, Shenzhen Base, South China Sea Fisheries Res Inst, Shenzhen 518121, Peoples R China

3.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China

关键词： Grouper; Viral nervous necrosis; Intestine microbiota; Gene transcription; Biomarkers

期刊名称：AQUACULTURE （ 影响因子：5.135； 五年影响因子：5.125 ）

ISSN： 0044-8486

年卷期： 2022 年 550 卷

页码：

收录情况： SCI

摘要： Groupers culture are severely affected by infectious diseases. Nervous necrosis virus (NNV) can destroy the nervous system and causes massive deaths. Intestinal microbiota is an important biological barrier against pathogen invasion. In this study, we investigated the changes in intestinal microbial community and gene transcription of tiger grouper following NNV infection. Compared with the control group, the richness and diversity of intestinal microbial was induced by NNV infection, with the increased level of Firmicutes (especially class Bacilli and Clostridia) and decreased levels of Proteobacteria and Bacteroidetes. Several genus such as Lactobacillus, Acinetobacter, Escherichia Shigella, Enterobacter, Flavobacterium and Stenotrophomonas were increased, while Alloprevotella, Bacteroides and Demequina were decreased. The carbohydrate metabolism of intestinal microbial was also decreased. The differentially expressed genes in head kidney were mainly associated with hemopoiesis and the development of immune system and hematopoietic or lymphoid organ. Several immune-related genes such as MHC class II antigen, CXC chemokine receptors (CXCR1 and CXCR4), heat shock proteins (HSP60, HSP70, HSP90), cytochrome C, immunoglobulin light chain and hepcidin were up-regulated, while interleukin (IL-8 nd IL-15), CXCR3 and complement (C1QL3 and C7) were down-regulated. These results revealed that NNV infection caused intestinal microbiota variation and affected the immunity of tiger grouper, which will be beneficial to utilize the characteristics of intestinal microbial to facilitate grouper healthy culture.

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