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The tyrosine phosphatase PTPN14 inhibits the activation of STAT3 in PEDV infected Vero cells

文献类型： 外文期刊

作者： Huang, Huimin 1 ; Li, Yongtao 1 ; Li, Dongliang 1 ; Wang, Li 2 ; Jiao, Wenqiang 3 ; Bai, Yilin 2 ; Zhang, Gaiping 1 ;

作者机构： 1.Henan Agr Univ, Coll Vet Med, Zhengzhou 450002, Peoples R China

2.Henan Acad Agr Sci, Key Lab Anim Immunol, Henan Prov Key Lab Anim Immunol, Minist Agr, Zhegnzhou 450002, Peoples R China

3.Henan Acad Agr Sci, Inst Anim Husbadnry & Vet Res, Zhegnzhou 450002, Peoples R China

4.Jiangsu Co Innovat Ctr Prevent & Control Importan, Yangzhou 225009, Jiangsu, Peoples R China

关键词： PEDV; Tyrosine phosphatase; PTPN14; STAT3; Dephosphorylation

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）

ISSN： 0378-1135

年卷期： 2022 年 267 卷

页码：

收录情况： SCI

摘要： Protein tyrosine phosphatase non-receptor type 14 (PTPN14) is a member of the protein tyrosine phosphatase (PTP) family which is a potential tumor suppressor. PTPs modulate the cellular level of tyrosine phosphorylation under normal and pathological conditions. Porcine epidemic diarrhea virus (PEDV) is one of the most important pathogens in the swine industry. Our previous membrane proteomics results showed that PTPN14 was markedly upregulated in PEDV-infected Vero cells. However, its biological roles in PEDV infection have not yet been investigated. In this study, we reported PTPN14 functions as a novel regulator of signal transducer and activator of transcription 3 (STAT3) phosphorylation during PEDV infection. Firstly, PTPN14 was markedly upregulated in PEDV-infected Vero cells with the decrease of STAT3 phosphorylation. Knockdown of PTPN14 or phosphatase inhibitor treatment promoted PEDV proliferation and increased the phosphorylation of STAT3 in Vero cells. On the contrary, overexpression of PTPN14 inhibits viral infection in Vero cells. Moreover, dephosphorylation of STAT3 by PTPN14 might occur in the cytoplasm but not in nucleus. Collectively, our results indicate that PTPN14 plays a negative role in regulating STAT3 activation in PEDV infected Vero cells and demonstrate another layer of regulation in PEDV infection.

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