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Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13

文献类型： 外文期刊

作者： Peng, Xiao-Ping 1 ; Li, Gang 1 ; Wang, Li-Mei 1 ; Wang, Qi 1 ; Wang, Cong 2 ; Ji, Li-Xia 1 ; Cao, Chen-Xi 1 ; Lin, Guo-Feng 1 ; Jiang, Zu-Yang 1 ; He, Zhuo-qian 1 ; Wang, Pei 3 ; Lou, Hong-Xiang 1 ;

作者机构： 1.Qingdao Univ, Sch Pharm, Dept Nat Med Chem & Pharmacognosy, Qingdao, Peoples R China

2.Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Nanning, Peoples R China

3.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Hainan Key Lab & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China

4.Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ, Jinan, Peoples R China

关键词： sorbicillinoid; trisorbicillinoid; Acremonium; endophyte; Fructus mori

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： Three new sorbicillinoids, including trimer trisorbicillinone E (1), acremosorbicillinoids A and B (2 and 3), and a new alkaloid acremokaloid A (4), and a new natural product 2S,3S-acetyl-beta-methyltryptophan (5), were isolated from an endophytic fungus Acremonium citrinum SS-g13, which is found in Fructus mori plant root. In addition, eight known sorbicillinoids (6-13) were also obtained. The new compound structures were established using NMR, HRESIMS spectra, and reported spectroscopic data. The absolute configurations of compounds 1-5, were determined by spectroscopic analysis, Snatzke's method, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. Compound 11 exhibited significant cholesterol efflux enhancing activity. A plausible biosynthesis pathway for the sorbicillinoids is discussed.

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