Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis
文献类型： 外文期刊
作者： Yang, Li 1 ; Wang, Qi 1 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Gai, Cui-Juan 1 ; Wu, You-Gen 3 ; Dai, Hao-Fu 1 ; Zhao, You-Xing 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Hainan, Peoples R China
3.Hainan Univ, Sanya Nanfan Res Inst, Sanya 572025, Peoples R China
关键词： Diaporthe sp.; Endophytic fungus; Cytochalasin; Cytotoxicity
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.9； 五年影响因子：2.8 ）
ISSN： 1612-1872
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Five new cytochalasins, diaporchalasins A-E (1-5), together with 14 known congeners (6-19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high-resolution electron spray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C-21 displayed cytotoxicity toward K562, BEL-7402, SGC-7901, A549, and HeLa cell lines with IC50 values ranging from 4.4 to 47.4 mu M. image
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