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Discovery of ganodecalone A, from Ganoderma calidophilum for the treatment of acute gastric ulcers by binding to ALOX5 via the MAPK/ NF-κB/iNOS signaling

文献类型： 外文期刊

作者： Liu, Yu 1 ; Li, Weikang 1 ; Yang, Li 3 ; Tong, Zhao 1 ; Wang, Zhen 4 ; Zhao, Youxing 3 ; Luo, Duqiang 1 ;

作者机构： 1.Hebei Univ, Inst Life Sci & Green Dev, Coll Life Sci, Baoding 071002, Peoples R China

2.Hebei Univ, Hebei Innovat Ctr Bioengn & Biotechnol, Baoding 071002, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med & Natl Key Lab Trop, Haikou 571101, Peoples R China

4.Hebei Univ Engn, Sch Med, Hebei Key Lab Med Data Sci, Handan 056038, Hebei, Peoples R China

关键词： Gastric ulcer; Ganoderma calidophilum; Ganodecalone A; Oxidative stress; Inflammation; MAPK/NF-kappa B/iNOS signalling

期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：5.4； 五年影响因子：5.4 ）

ISSN： 0378-8741

年卷期： 2025 年 351 卷

页码：

收录情况： SCI

摘要： Ethnopharmacological relevance: "Li medicine" Ganoderma calidophilum is a rare and unique medicinal fungus native to Hainan, China, traditionally used to relieve stomach pain and treat gastric diseases. However, its medicinal applications lack scientific validation despite its prominent role in ethnomedicine. Aim of the study: This study aimed to evaluate the therapeutic potential of G. calidophilum extract against gastric ulcer (GU), isolate its main bioactive compound (GDA), and elucidate the underlying mechanisms of action. Materials and methods: In vivo, acute gastric mucosal-injured mice were observed for mucosal symptoms, and levels of IL-6, TNF-alpha, SOD, and MDA were measured. In vitro, ethanol-damaged GES-1 cells were used to test the effects of G. calidophilum extract and GDA. 28 compounds were isolated from the extract, and network pharmacology and molecular docking studied GDA influence on ALOX5 and NF-kappa B. Results: The extract improved mouse symptoms regulated inflammatory and oxidative stress markers. GDA, the key anti-inflammatory compound, repaired cell damage, reduced inflammation and oxidative stress. Network and docking results showed GDA inhibited early-stage inflammation. Conclusions: G. calidophilum extract exhibits potent anti-GU activity, primarily attributed to GDA, which alleviates gastric mucosal inflammation by binding to ALOX5 and modulating MAPK/NF-kappa B/iNOS signaling and lipid peroxidation. These findings validate its traditional use and provide a mechanistic basis for its therapeutic application in acute GU.

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