Formation of N-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps
文献类型： 外文期刊
作者： Li, Zhang-Hai 1 ; Dai, Yu 1 ; Zhou, Jing 2 ; Yang, Li 3 ; Li, Shu-Ming 1 ;
作者机构： 1.Philipps Univ Marburg, Inst Pharmazeut Biol & Biotechnol, Fachbereich Pharm, D-35037 Marburg, Germany
2.Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources, Minist Educ, Haikou 570200, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China
4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：5.0； 五年影响因子：4.6 ）
ISSN： 1523-7060
年卷期： 2025 年 27 卷 10 期
页码：
收录情况： SCI
摘要： Gene duplication significantly contributes to the diversification of biosynthetic potential and increases the structural diversity of secondary metabolites. Here, we report the second alkyl salicylaldehyde derivative biosynthetic gene cluster in Penicillium roqueforti, being responsible for the formation of ethanolamine-containing derivatives. Heterologous expression and feeding experiments provided evidence for their formation via collaboration and modification with one cytochrome P450 and two flavin-containing monooxygenases in a highly ordered manner before and after ethanolamine incorporation.
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