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Chemical composition of the endogenous fungus Fusarium sp. L-3 derived from Chinese Qinan agarwood

文献类型： 外文期刊

作者： Han, Ming-Li 1 ; Ma, Qing-Yun 2 ; Yang, Li 2 ; Xie, Qing-Yi 2 ; Guo, Jiao-Cen 2 ; Dai, Hao-Fu 2 ; Xiao, Na 1 ; Zhao, You-Xing 2 ;

作者机构： 1.Shandong Agr Univ, Coll Agr, Tai An, Peoples R China

2.CATAS, Natl Key Lab Trop Crop Breeding, Haikou, Peoples R China

3.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Peoples R China

关键词： Fusarium sp; Chinese agarwood 'Qi-Nan'; secondary metabolites; anti-inflammatory; alpha-glucosidase inhibition

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）

ISSN： 1478-6419

年卷期： 2025 年

页码：

收录情况： SCI

摘要： One undescribed compound named fusagarone A (1) and ten secondary metabolites (2-11) were isolated from the endophytic fungus Fusarium sp. L-3 derived from Chinese agarwood 'Qi-Nan'. The structure of 1 was elucidated by NMR spectroscopy as well as HRESIMS data. All compounds were measured for anti-inflammatory, cytotoxicity activity and alpha-glucosidase inhibitory activities. Among them, compound 11 potently suppressed nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages with IC50 value of 4.78 mu M. Moreover, compound 11 exhibited potent inhibitory effect on alpha-glucosidase with IC50 value of 42.88 mu M, which was further clarified by means of the enzyme kinetic analysis and molecular docking simulations.

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