Chemical constituents from the fruiting bodies of Lanmaoa asiatica and their anti-inflammatory activity
文献类型： 外文期刊
作者： Zhang, Bin 1 ; Yang, Li 1 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Guo, Jiao-Cen 1 ; Dai, Hao-Fu 1 ; Chen, Jun-Wen 3 ; Zhao, You-Xing 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou 571101, Peoples R China
3.Yunnan Agr Univ, Coll Agron & Biotechnol, Kunming 650201, Peoples R China
关键词： Lanmaona asiatica; Chemical constituents; Ergosterol; Anti; inflammatory activity
期刊名称：FITOTERAPIA （ 影响因子：2.6； 五年影响因子：3.0 ）
ISSN： 0367-326X
年卷期： 2025 年 183 卷
页码：
收录情况： SCI
摘要： Four new compounds, dimethyl 3,5-bis(4-hydroxyphenyl)-1H-pyrrole-2,4-dicarboxylate (1), dimethyl 3,5-bis(4hydroxyphenyl)-1H-furan-2,4-dicarboxylate (2), 5 alpha-hydroxy-6 beta-methoxy-ergosta-7,22E-dien-3-one (3), and 6methoxy-strophasterol E (4), together with sixteen known compounds (5-20), were isolated from the fruiting bodies of Lanmaoa asiatica. The structures of new compounds were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Among them, compounds 2, 4, 7, and 9 exhibited antiinflammatory activity by suppressing NO production in lipopolysaccharide-stimulated RAW264.7 macrophages with IC50 values ranging from 20.3 to 47.3 mu M.
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