文献类型： 外文期刊
作者： Cai, Ying-Ying 1 ; Li, Lin 1 ; Zhu, Xue-Ming 1 ; Lu, Jian-Ping 3 ; Liu, Xiao-Hong 2 ; Lin, Fu-Cheng 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Managing Biot & Chem Treats Qual & S, Hangzhou, Peoples R China
2.Zhejiang Univ, Inst Biotechnol, State Key Lab Managing Biot & Chem Treats Qual & S, Hangzhou, Peoples R China
3.Zhejiang Univ, Coll Life Sci, Hangzhou, Peoples R China
关键词： Atg1; ULK1 complex; autophagy; TOR; AMPK; Snf1; regulatory mechanism
期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Autophagy, an evolutionarily conserved cellular degradation pathway in eukaryotes, is hierarchically regulated by autophagy-related genes (Atgs). The Atg1/ULK1 complex is the most upstream factor involved in autophagy initiation. Here?we summarize the recent studies on the structure and molecular mechanism of the Atg1/ULK1 complex in autophagy initiation, with a special focus on upstream regulation and downstream effectors of Atg1/ULK1. The roles of pathogenicity and autophagy aspects in Atg1/ULK1 complexes of various pathogenic hosts, including plants, insects, and humans, are also discussed in this work based on recent research findings. We establish a framework to study how the Atg1/ULK1 complex integrates the signals that induce autophagy in accordance with fungus to mammalian autophagy regulation pathways. This framework lays the foundation for studying the deeper molecular mechanisms of the Atg1 complex in pathogenic fungi.
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