Integrative analysis of GWAS and transcriptome reveals p53 signaling pathway mediates resistance to visceral white-nodules disease in large yellow croaker
文献类型： 外文期刊
作者： Bai, Yulin 1 ; Qu, Ang 1 ; Liu, Yue 1 ; Chen, Xintong 1 ; Wang, Jiaying 1 ; Zhao, Ji 1 ; Ke, Qiaozhen 1 ; Chen, Lin 1 ; Chi, Hongshu 4 ; Gong, Hui 4 ; Zhou, Tao 1 ; Xu, Peng 1 ;
作者机构： 1.Xiamen Univ, Coll Ocean & Earth Sci, Fujian Key Lab Genet & Breeding Marine Organisms, Xiamen 361102, Peoples R China
2.Xiamen Univ, Coll Ocean & Earth Sci, State Key Lab Marine Environm Sci, Xiamen 361102, Peoples R China
3.Ningde Fufa Fisheries Co Ltd, State Key Lab Large Yellow Croaker Breeding, Ningde 352130, Peoples R China
4.Fujian Acad Agr Sci, Biotechnol Inst, Fuzhou, Fujian, Peoples R China
5.Xiamen Univ, Coll Ocean & Earth Sci, Xiamen 361102, Peoples R China
关键词： Larimichthys crocea; Visceral white -nodules disease; GWAS; RNA-seq; p53 signaling pathway; Disease resistance
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.622； 五年影响因子：4.799 ）
ISSN： 1050-4648
年卷期： 2022 年 130 卷
页码：
收录情况： SCI
摘要： Visceral white-nodules disease (VWND), caused by Pseudomonas plecoglossicida, is one of the primary causes of morbidity and mortality in large yellow croaker aquaculture. Host disease resistance is a heritable trait that involves complex regulatory processes. However, the regulatory mechanism of bacterial resistance in large yellow croaker is still unclear. This study attempted to systematically evaluate the major genetic loci and transcriptional regulatory mechanisms associated with the resistance to VWND in large yellow croaker by crossover method studies. A large population of large yellow croaker was challenged with P. plecoglossicida, with survival time recorded and samples were taken for genotyping. Meanwhile, spleen samples that were used for RNA-seq to compare their transcriptomic profiles before and after infection were taken from resistant pop-ulations (RS) and susceptible control populations (CS) bred using the genomic selection (GS) technique. Genome-wide association analyses using 46 K imputed SNP genotypes highlighted that resistance is a polygenic trait. The integrative analysis results show the co-localization of the cd82a gene between disease resistance-related genetic loci and comparative transcriptional analysis. And functional enrichment analysis showed differential enrich-ment of the p53 signaling pathway in RS and CS groups, suggesting that there may be cd82a-mediated p53 signaling pathway activation for VWND resistance. This large-scale study provides further evidence for the heritability and transcriptional regulatory mechanisms of host inheritance of VWND resistance.
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